Results 1 to 10 of about 6,613 (165)

Comprehensive safety evaluation of Withania somnifera (Ashwagandha): an AI-driven meta-analysis and quantitative structure–activity relationship based toxicity assessment [PDF]

open access: yesFrontiers in Nutrition
ObjectiveThis study evaluates the safety profiles of Withania somnifera (Ashwagandha), an adaptogenic herb prevalent in Ayurvedic medicine, focusing on liver and reproductive toxicity.
Yotam Ronen   +5 more
doaj   +3 more sources

Effect of ashwagandha (Withania somnifera) on endocrine and reproductive traits in Awassi sheep [PDF]

open access: yesOpen Veterinary Journal
Background: Although ashwagandha, or Withania somnifera, is used as a broad-spectrum treatment to treat a wide range of illnesses, including reproductive issues, and to improve fertility, it is also considered a potent adaptogen and anti-stressor that ...
Ashraf Kamil Azeez   +4 more
doaj   +3 more sources

Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review

open access: yesPharmaceutics, 2023
In recent years, there has been a significant surge in reports on the health-promoting benefits of winter cherry (Withania somnifera), also known as Ashwagandha.
Magdalena Paczkowska   +2 more
exaly   +2 more sources

Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause

open access: yesPharmaceuticals, 2023
Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses in patients with acute liver injury without an obvious etiology.
Bojana Vidović   +2 more
exaly   +3 more sources

Plant Part–Specific Differences in Ashwagandha (Withania somnifera): A Comparative Evaluation of Root and Leaf Evidence for Safety and Regulation [PDF]

open access: yesFood Sci Nutr
This review contrasts the root and leaf of Withania somnifera (ashwagandha) across phytochemistry, clinical evidence, and regulatory context. Root preparations are dominated by withanolide A, D, and glyco‐withanolides, with multiple randomized controlled trials supporting reductions in stress, anxiety, and insomnia alongside a favorable safety profile.
Dutta A, Gupta J.
europepmc   +2 more sources

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 4792-4801, August 2026.
The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may ...
Elizabeth M. Williamson, T. Brendler
semanticscholar   +2 more sources

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 4845-4857, August 2026.
Over the last decade, ashwagandha ( Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure ...
T. Brendler   +5 more
semanticscholar   +2 more sources

Safety of 12‐Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 4802-4812, August 2026.
Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root
Jaising Salve   +6 more
semanticscholar   +2 more sources

The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance

open access: yesFrontiers in Nutrition
Ashwagandha or Withania somnifera is an herbal plant belonging to the Solanaceae family. Because of its wide range of phytochemicals, ashwagandha root extract has been used in numerous research studies, either alone or in conjunction with other natural ...
Shiyi Guo, Mohammad J. Rezaei
doaj   +2 more sources

Treatment With Ashwagandha-Derived Exosome-Like Nanovesicles Up-Regulates VEGF-A Production and Promotes Human Hair Growth Ex Vivo. [PDF]

open access: yesExp Dermatol
ABSTRACT Human‐derived exosomes show promise for hair loss treatment but may pose safety concerns, including inflammatory responses and pathogen transmission. Here, we investigated whether plant‐derived exosomes, whose isolation can be standardized, and which show lower compositional complexity and no immunogenicity, represent a valid alternative.
Le Riche A   +12 more
europepmc   +2 more sources

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