Results 161 to 170 of about 148,555 (193)
Advanced Science, EarlyView.The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang +13 more
wiley +1 more source
Advanced Science, EarlyView.This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang +14 more
wiley +1 more source
Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke
Advanced Science, EarlyView.Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber +6 more
wiley +1 more source
Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation
Advanced Science, EarlyView.The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu +8 more
wiley +1 more source
A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
Advanced Science, EarlyView.The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye +21 more
wiley +1 more source
SNAP online purchasing and the healthfulness of food purchases
Applied Economic Perspectives and Policy, EarlyView.Abstract This paper investigates the effects of the SNAP Online Purchasing Pilot expansion (SNAP OPP) on SNAP households' online grocery shopping behaviors and the healthfulness of their food‐at‐home purchases. We explore quasi‐experimental estimates of the impact of online purchasing by leveraging a unique natural experiment: the staggered ...
I‐Hung Kuan +3 more
wiley +1 more source
Advanced Energy and Sustainability Research, EarlyView.The decomposition of single‐use plastics by selected insects is often sustained or enhanced through the addition of natural supplements or feeds. Herein, the rationale behind these choices is demonstrated by examining the effects of selected amino acids and water as enhancers in the biodegradation of polystyrene by mealworms.
Xinbo Wang +6 more
wiley +1 more source
AGING MEDICINE, EarlyView.This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang +2 more
wiley +1 more source
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Journal of Sports Sciences, 2004
For the athlete training hard, nutritional supplements are often seen as promoting adaptations to training, allowing more consistent and intensive training by promoting recovery between training sessions, reducing interruptions to training because of illness or injury, and enhancing competitive performance.
Ron J, Maughan +2 more
openaire +2 more sources
For the athlete training hard, nutritional supplements are often seen as promoting adaptations to training, allowing more consistent and intensive training by promoting recovery between training sessions, reducing interruptions to training because of illness or injury, and enhancing competitive performance.
Ron J, Maughan +2 more
openaire +2 more sources