Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette +13 more
wiley +1 more source
Associations of Sleep and Shift Work With Osteoarthritis Risk
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik +5 more
wiley +1 more source
Role of domiciliary and family carers in individualised nutrition support for older adults living in the community [PDF]
Agarwal, Ekta +3 more
core +1 more source
Modernising Coeliac Disease Dietitian Follow-Up: Engagement and Functionality of a Digital Annual Review. [PDF]
Abbott O +3 more
europepmc +1 more source
The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis [PDF]
Annois, Brigitte +7 more
core
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier +12 more
wiley +1 more source
An Audit of the Use of Total Parenteral Nutrition: Are We Using It Correctly? [PDF]
Kumar A, Taggarsi M, Rai S.
europepmc +1 more source
Objective This study aimed to investigate potential moderators influencing the effects of manual therapy and exercise therapy on pain and functional outcomes in individuals with knee and/or hip osteoarthritis, using data from the MOA trial. Design This is a secondary analysis of data from the MOA trial that compared the clinical effectiveness of manual
Daniel Cury Ribeiro +2 more
wiley +1 more source
The malnutrition screening tool in geriatric rehabilitation: A comparison of validity when completed by health professionals with and without malnutrition screening training has implications for practice [PDF]
Isenring, Elizabeth +2 more
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source

