Results 101 to 110 of about 1,253,047 (364)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Do we accurately measure what we consume?

Environmental Research Letters
Understanding how consumption patterns affect the environment and shape well-being hinges on the rationale that the data collected on what is consumed, who consumes it, and where it is consumed are indeed accurate.
Benjamin P Goldstein, Dimitrios Gounaridis, Joshua P Newell, Rylie Pelton, Jennifer Schmitt   +4 more
doaj   +1 more source

Exploring Dietary Interventions in Autism Spectrum Disorder

Foods
Autism spectrum disorder (ASD) involves social communication difficulties and repetitive behaviors, and it has a growing prevalence worldwide. Symptoms include cognitive impairments, gastrointestinal (GI) issues, feeding difficulties, and psychological ...
Ingrid Daniela Pérez-Cabral, Ariadna Thalía Bernal-Mercado, Alma Rosa Islas-Rubio, Guadalupe Miroslava Suárez-Jiménez, Miguel Ángel Robles-García, Andrés Leobardo Puebla-Duarte, Carmen Lizette Del-Toro-Sánchez   +6 more
doaj   +1 more source

Suitability of calorie fortified diets for improving the production of Clarias gariepinus broodstock and fry [PDF]

, 1993
The findings are presented of an experiment conducted to determine the adequate level of calorie in diets that is necessary to bring Clarias gariepinus female broodstock to grand stage. The effect of different calorie level on the quality and quantity of
Aliu, B.S., Faturoti, E.O., Omitoyin, B.O.   +2 more
core  

Salt intake and regulation in two passerine nectar drinkers: white-bellied sunbirds and New Holland honeyeaters [PDF]

, 2012
Avian nectarivores face the dilemma of having to conserve salts while consuming large volumes of a dilute, electrolyte-deficient diet. This study evaluates the responses to salt solutions and the regulation of salt intake in white-bellied sunbirds ...
Fleming, P.A., Nicolson, S.W., Purchase, C.   +2 more
core   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effect of Lupinus albus as protein supplement on yield, constituents, clotting properties and fatty acid composition in ewes' milk [PDF]

, 2006
The effect of feeding lupin seeds (Lupinus albus L.) as an alternative protein source in ewe diets was investigated. Two groups of 18 Sarda ewes were fed two different isonitrogenous diets: with lupin (L) seed, given after 12 h soaking, or soybean meal ...
DI FRANCIA, ANTONIO, LAMBIASE, GIANFRANCO, M. T. MARESCA DI SERRACAPRIOLA, MASUCCI, FELICIA, PROTO, VINCENZO, ROMANO, RAFFAELE, VARRICCHIO, MARIA LUISA   +6 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Vegetable, livestock and agroindustrial products and byproducts: An alternative tilapia feeding [PDF]

Revista Bio Ciencias, 2014
In the culture of tilapia limited supply and high cost of fish meal have forced nutritionists to consider alternative sources of protein. Due to the importance of the products and by-products in fish feed, this paper aims to show the alternatives ...
González Salas, R., Romero Cruz, O., Valdivié Navarro, M., Ponce-Palafox, J.T.   +3 more
doaj