Results 111 to 120 of about 2,344 (223)

Deconstrucción y teología negativa. El juego entre différance y diferencia ontológica

open access: yesEstudios de Filosofía, 2014
Pese a las recurrentes advertencias de Derrida acerca de no pasar por alto la frontera que separa la deconstrucción de la teología negativa, malentendido que, según él, desvirtuaría el radical alcance crítico pretendido por la primera, su intento por ...
Diana María Muñoz González
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

HEİDEGGER VE DERRİDA'NIN FARKI: DİFFERANCE, METAFİZİĞİN SINIRINDAKİ OYUN

open access: yesFelsefe Dünyası, 2008
HEİDEGGER VE DERRİDA'NIN FARKI: DİFFERANCE, METAFİZİĞİN SINIRINDAKİ ...
Cihan Camcı
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Derridian différance. Is a Spelling Mistake Translatable? [PDF]

open access: yes, 2015
The article examines Polish translations of the Derridian term différance. Polish philosophical discourse uses the following renditions of différance: róż(ni(c) oś)ć by Bogdan Banasiak, różNICa by Tadeusz Sławek, gra-na-zwłokę-o-różnicę by Stanisław ...
Marzec, Andrzej
core  

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