Results 151 to 160 of about 4,636,999 (250)

Boundedness, persistence and stability for classes of forced difference equations arising in population ecology. [PDF]

J Math Biol, 2019
Franco D, Guiver C, Logemann H, Perán J.   +3 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Corrigendum to "Numerical investigation of singularly perturbed time lag parabolic differential-difference equations" [Heliyon Volume 11, Issue 1, January 2025, Article e41215]. [PDF]

Heliyon
Daba IT, Melesse WG, Gelu FW, Kebede GD.
europepmc   +1 more source

Oscillations in deviating difference equations using an iterative technique. [PDF]

J Inequal Appl, 2017
Chatzarakis GE, Jadlovská I.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A multidimensional momentum chain model for tennis matches based on difference equations. [PDF]

PLoS One
Wang J, Guo S, Zhou Y.
europepmc   +1 more source

On homogeneous second order linear general quantum difference equations. [PDF]

J Inequal Appl, 2017
Faried N, Shehata EM, El Zafarani RM.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Numerical investigation of singularly perturbed time lag parabolic differential-difference equations. [PDF]

Heliyon
Daba IT, Melesse WG, Gelu FW, Kebede GD.
europepmc   +1 more source

Entire solutions of nonlinear differential-difference equations. [PDF]

Springerplus, 2016
Li C, Lü F, Xu J.
europepmc   +1 more source