Results 61 to 70 of about 90,096 (231)

An open source code for modeling radio wave propagation in earth’s ionosphere

Frontiers in Astronomy and Space Sciences
We present FARR (Finite-difference time-domain ARRay), an open source, high-performance, finite-difference time-domain (FDTD) code. FARR is specifically designed for modeling radio wave propagation in collisional, magnetized plasmas like those found in ...
Alexander Green, William J. Longley, Meers M. Oppenheim, Matthew A. Young   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Vectorized numerical algorithms for the solution of continuum mechanics problems

Научно-технический вестник информационных технологий, механики и оптики
The aim of the work is to study the possibilities provided by new information technologies, object-oriented programming tools and modern operating systems for solving boundary value problems of continuum mechanics described by partial differential ...
N. A. Brykov, K. N. Volkov, V. N. Emelyanov   +2 more
doaj   +1 more source

A Stress Analysis of Some Fundamental Specimens of Soft-Matter Quasicrystals with Eightfold Symmetry Based on Generalized Dynamics

Advances in Materials Science and Engineering, 2019
This paper reports a stress analysis of some fundamental samples made of soft-matter quasicrystals with 8-fold symmetry based on the generalized dynamics.
Fang Wang, Hui Cheng, Tian-You Fan, Hai-Yun Hu   +3 more
doaj   +1 more source

A 1D-FDM Transmission Line Model for Partial Discharge Current Simulations Validated Against Needle-Plate HVDC Laboratory Experiments: Calculations of Ionized Air Conductivity [PDF]

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
In this paper, we present a novel numerical model for simulating partial discharges (PDs) transient currents excited by high-voltage DC (HVDC) systems.
Rodrigo M. S. de Oliveira, Nathan M. Lopes, Júlio A. S. do Nascimento   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical Solution of Two-Dimensional Advection Diffusion Equation for Multiphase Flows in Porous Media Using a Novel Meshfree Method of Lines.

International Journal of Applied Sciences and Smart Technologies
This study proposes a novel Meshfree Method of Lines (MFMOL), in strong form formulation, to solve multiphase flows of solute transport modelled by two-dimensional (2D) Advection Diffusion Equations (ADE).
Jamiu Abiodun Kazeem, Franklin Olusodayo Ogunfiditimi   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Application of the Curvilinear Coordinate Method for the Numerical Solution of the Navier–Stokes Equations in Domains with Complex Boundaries

Computation
In this paper, the coordinate transformation method is applied to the Navier–Stokes equations expressed in terms of the stream function and vorticity formulation.
Nurlan Temirbekov, Gayaz Khakimzyanov, Ainur Kerimakyn   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source