Results 71 to 80 of about 90,096 (231)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Impedance Calculating Method of Steel Mill Short Net Conductors Based on Finite Element Method

IEEE Access
The short net is a high-current system with complex geometric shapes in electric furnace steelmaking. The short net impedance calculation is a necessary foundation and basis for designing short net parameters.
Qiao Ma, Bing Tong, Xiangqian Tong, Teng Zhao, Yadan Shang, Fenghui Zhao, Dong Zhang   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Meshfree modelling of magnetotelluric and controlled-source electromagnetic data for conductive earth models with complex geometries

Frontiers in Earth Science
Geophysical electromagnetic survey methods are particularly effective in locating conductive mineral deposits or mineralization zones in a mineral resource exploration.
Jianbo Long
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

OpenCL-Based FPGA Accelerator for 3D FDTD with Periodic and Absorbing Boundary Conditions

International Journal of Reconfigurable Computing, 2017
Finite difference time domain (FDTD) method is a very poplar way of numerically solving partial differential equations. FDTD has a low operational intensity so that the performances in CPUs and GPUs are often restricted by the memory bandwidth. Recently,
Hasitha Muthumala Waidyasooriya, Tsukasa Endo, Masanori Hariyama, Yasuo Ohtera   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Seismic wave modeling of fluid-saturated fractured porous rock: including fluid pressure diffusion effects of discretely distributed large-scale fractures [PDF]

Solid Earth
The scattered seismic waves of fractured porous rock are strongly affected by the wave-induced fluid pressure diffusion effects between the compliant fractures and the stiffer embedding background. To include these poroelastic effects in seismic modeling,
Y. Qi, Y. Qi, X. Chen, X. Chen, Q. Zhao, Q. Zhao, X. Luo, C. Feng   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The CFS-PML for 2D Auxiliary Differential Equation FDTD Method Using Associated Hermite Orthogonal Functions

International Journal of Antennas and Propagation, 2017
The complex frequency shifted (CFS) perfectly matched layer (PML) is proposed for the two-dimensional auxiliary differential equation (ADE) finite-difference time-domain (FDTD) method combined with Associated Hermite (AH) orthogonal functions.
Feng Jiang, Xiao-Ping Miao, Feng Lu, Li-Yuan Su, Yao Ma   +4 more
doaj   +1 more source