Results 141 to 150 of about 12,099,179 (254)

Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability. [PDF]

Elife
Wethington D, Ahmad S, Potempa M, Giuliani G, Aguilar OA, Poudel M, Grassmann S, Stewart WC, Adams NM, Sun JC, Lanier LL, Das J.   +11 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictability of maxillary transverse changes with Invisalign in adults: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore)
XiangGang H, Jia Q, Jie Y, Yani C, Chao L, Guo J, Bai M.   +6 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Medicaid Expansion and Mortality Among Patients With Colorectal Cancer.

JAMA Netw Open
Akinyemi O, Oyebanji O, Oluborode B, Akinwumi B, Ogunyankin F, Hughes K, Fullum T, Chu Q, Nalamati S, Abouljoud M, Nembhard C, Reickert C.   +11 more
europepmc   +1 more source

Early-Onset Preeclampsia-Derived hUC-MSCs Exhibit Accelerated Initial Culture Kinetics Without Sustained Growth Advantage: A Comparative In Vitro Study. [PDF]

Stem Cells Int
Alptekin İ, Alptekin B, Erkan E, Celikkan FT, Hendem DU, Şahin D, Can A.   +6 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Volume change with gantenerumab: Impact of amyloid-related imaging abnormalities and amyloid removal. [PDF]

Alzheimers Dement
Tonietto M, Silvestri E, Belder CRS, Barkhof F, Fox NC, Smith J, Klein G.   +6 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Dentoalveolar outcomes and the long-term stability of tooth-tissue-borne versus bone-tissue-borne rapid maxillary expansion in growing patients: A 5.8-year follow-up. [PDF]

Korean J Orthod
Akin M, Mutluol EU, Gunes TE, Yildirim M.   +3 more
europepmc   +1 more source