Results 101 to 110 of about 954,644 (280)

Dunkl-Type Operators with Projection Terms Associated to Orthogonal Subsystems in Root System

Symmetry, Integrability and Geometry: Methods and Applications, 2013
In this paper, we introduce a new differential-difference operator T_ξ (ξ∈R^N) by using projections associated to orthogonal subsystems in root systems.
Fethi Bouzeffour
doaj   +1 more source

Difference Krichever-Novikov operators

, 2014
In this paper we study commuting difference operators of rank two. We introduce an equation on potentials $V(n),W(n)$ of the difference operator $L_4=(T+V(n)T^{-1})^2+W(n)$ and some additional data. With the help of this equation we find the first examples of commuting difference operators of rank two corresponding to spectral curves of higher genus.
Mauleshova, Gulnara S., Mironov, Andrey E.   +1 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Special Functions of Hypercomplex Variable on the Lattice Based on SU(1,1)

Symmetry, Integrability and Geometry: Methods and Applications, 2013
Based on the representation of a set of canonical operators on the lattice hZn, which are Clifford-vector-valued, we will introduce new families of special functions of hypercomplex variable possessing su(1,1) symmetries. The Fourier decomposition of the
Nelson Faustino
doaj   +1 more source

Fuzzy Difference Operators for Spatial Change Detection in 2D Spatial Scene

Cybergeo, 2011
Fuzzy difference operators are used in different fields of decision making processes, image analysis and computer vision applications. Change detection in a spatial scene is the basic issue in modeling relative motion between object pair. Many approaches
Nadeem Salamat, El-hadi Zahzah
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Poisson Geometry of Difference Lax Operators, and Difference Galois Theory, or Quantum groups from Poisson brackets anomalies

EPJ Web of Conferences, 2014
We discuss the lift of Poisson structures associated with auxiliary linear problems for the differential and difference Lax equations to the space of wave functions.
Semenov-Tian-Shansky Michael
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source