Results 51 to 60 of about 28,027 (297)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Punzi-loss:

European Physical Journal C: Particles and Fields, 2022
We present the novel implementation of a non-differentiable metric approximation and a corresponding loss-scheduling aimed at the search for new particles of unknown mass in high energy physics experiments.
F. Abudinén, M. Bertemes, S. Bilokin, M. Campajola, G. Casarosa, S. Cunliffe, L. Corona, M. De Nuccio, G. De Pietro, S. Dey, M. Eliachevitch, P. Feichtinger, T. Ferber, J. Gemmler, P. Goldenzweig, A. Gottmann, E. Graziani, H. Haigh, M. Hohmann, T. Humair, G. Inguglia, J. Kahn, T. Keck, I. Komarov, J.-F. Krohn, T. Kuhr, S. Lacaprara, K. Lieret, R. Maiti, A. Martini, F. Meier, F. Metzner, M. Milesi, S.-H. Park, M. Prim, C. Pulvermacher, M. Ritter, Y. Sato, C. Schwanda, W. Sutcliffe, U. Tamponi, F. Tenchini, P. Urquijo, L. Zani, R. Žlebčík, A. Zupanc   +45 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The third axiom of filling properties

Examples and Counterexamples
Since its first appearance in 1983, the filled function method, which was initiated to solve global optimization problems, has developed very rapidly.
Ridwan Pandiya
doaj   +1 more source

A general cubic spline smooth semi-supervised support vector machine

工程科学学报, 2015
This article is focused on the non-smooth problem of the semi-supervised support vector machine optimization model. A smooth semi-supervised support vector machine model was established. A general cubic spline function with 2 times differentiable at zero
ZHANG Xiao-dan, MA Jing-gai
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

About Non-differentiable Functions

Journal of Mathematical Analysis and Applications, 2001
\textit{K. M. Kolwankar} and \textit{A. D. Gangal} [``Fractional differentiability of nowhere differentiable functions and dimensions'', Chaos, 6, No.~4, 505-513 (1996; Zbl 1055.26504)] introduced a certain ``localization'' \(d^\alpha f(x)\) of the Riemann-Liouville fractional derivative to study the local behaviour of nowhere differentiable functions.
Ben Adda, Fayçal, Cresson, Jacky
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source