Results 51 to 60 of about 640,277 (338)

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Optimizing Non-Differentiable Metrics for Hashing

IEEE Access, 2021
Image hashing embeds the image to binary codes which can boost the efficiency of approximately nearest neighbors search. F-measure is a widely-used metric for evaluating the performance of hashing methods.
Yiwen Wei, Dayong Tian, Jiao Shi, Yu Lei
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Gateaux Differentiability of Convex Functions and Weak Dentable Set in Nonseparable Banach Spaces

Journal of Function Spaces, 2019
In this paper, we prove that if C⁎⁎ is a ε-separable bounded subset of X⁎⁎, then every convex function g≤σC is Ga^teaux differentiable at a dense Gδ subset G of X⁎ if and only if every subset of ∂σC(0)∩X is weakly dentable.
Shaoqiang Shang, Yunan Cui
doaj   +1 more source

A general cubic spline smooth semi-supervised support vector machine

工程科学学报, 2015
This article is focused on the non-smooth problem of the semi-supervised support vector machine optimization model. A smooth semi-supervised support vector machine model was established. A general cubic spline function with 2 times differentiable at zero
ZHANG Xiao-dan, MA Jing-gai
doaj   +1 more source

Punzi-loss:

European Physical Journal C: Particles and Fields, 2022
We present the novel implementation of a non-differentiable metric approximation and a corresponding loss-scheduling aimed at the search for new particles of unknown mass in high energy physics experiments.
F. Abudinén, M. Bertemes, S. Bilokin, M. Campajola, G. Casarosa, S. Cunliffe, L. Corona, M. De Nuccio, G. De Pietro, S. Dey, M. Eliachevitch, P. Feichtinger, T. Ferber, J. Gemmler, P. Goldenzweig, A. Gottmann, E. Graziani, H. Haigh, M. Hohmann, T. Humair, G. Inguglia, J. Kahn, T. Keck, I. Komarov, J.-F. Krohn, T. Kuhr, S. Lacaprara, K. Lieret, R. Maiti, A. Martini, F. Meier, F. Metzner, M. Milesi, S.-H. Park, M. Prim, C. Pulvermacher, M. Ritter, Y. Sato, C. Schwanda, W. Sutcliffe, U. Tamponi, F. Tenchini, P. Urquijo, L. Zani, R. Žlebčík, A. Zupanc   +45 more
doaj   +1 more source

Differential Equations of General Genus Hyperelliptic $\wp$ Functions [PDF]

arXiv, 2023
We review the Baker's method to obtain differential equations of the general genus hyperelliptic $\wp$ functions. Further, we demonstrate to obtain differential equations of genus four hyperelliptic differential equations, which agree with our previous result.
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

A Language for Differentiable Functions [PDF]

, 2013
We introduce a typed lambda calculus in which real numbers, real functions, and in particular continuously differentiable and more generally Lipschitz functions can be defined. Given an expression representing a real-valued function of a real variable in this calculus, we are able to evaluate the expression on an argument but also evaluate the L ...
DI GIANANTONIO, Pietro, Abbas Edalat
openaire   +3 more sources