Results 71 to 80 of about 13,863,270 (332)

Nonoscillatory functional-differential equations [PDF]

open access: yesPacific Journal of Mathematics, 1984
Our aim in this paper is to obtain sufficient conditions under which certain functional differential equations have a " large" number of nonoscillatory solutions. Using the characteristic equation of a "majorant" delay differential equation with constant coefficients and Schauder's fixed point theorem, we obtain conditions under which the functional ...
Ladas, G.   +2 more
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Differentiability Properties of the Pre-Image Pressure

open access: yesDiscrete Dynamics in Nature and Society, 2012
We study the differentiability properties of the pre-image pressure. For a TDS (X,T) with finite topological pre-image entropy, we prove the pre-image pressure function Ppre(T,•) is Gateaux differentiable at f∈C(X,R) if and only if Ppre(T,•) has a unique
Kesong Yan, Fanping Zeng, Gengrong Zhang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On the extension of differentiable functions [PDF]

open access: yesBulletin of the American Mathematical Society, 1944
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Surjective isometries on vector-valued differentiable function spaces

open access: yes, 2019
In this article, we investigate the surjective linear isometries between the differentiable function spaces Cp0(X,E) and Cq0(Y,F), where X, Y are open subsets of R and E, F are strictly convex Banach spaces with dimension greater than 1.
Lei Li   +3 more
core   +1 more source

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