Results 71 to 80 of about 5,188,633 (246)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

An Implicit-Function Theorem for B-Differentiable Functions [PDF]

, 1988
A function from one normed linear space to another is said to be Bouligand differentiable (B-differentiable) at a point if it is directionally differentiable there in every direction, and if the directional derivative has a certain uniformity property ...
Robinson, S.M.
core   +1 more source

Differentiable Iterated Function Systems [PDF]

This preliminary paper presents initial explorations in rendering Iterated Function System (IFS) fractals using a differentiable rendering pipeline. Differentiable rendering is a recent innovation at the intersection of computer graphics and machine ...
Scott, Cory Braker
core   +1 more source

Extending the Applicability of a Two-Step Chord-Type Method for Non-Differentiable Operators

Mathematics, 2019
The semi-local convergence analysis of a well defined and efficient two-step Chord-type method in Banach spaces is presented in this study. The recurrence relation technique is used under some weak assumptions.
Ioannis K. Argyros, Neha Gupta, J. P. Jaiswal   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Interpolation and Approximation of Non Differentiable Function Using Polynomial [PDF]

, 2007
In any approximation problem, we concerned with a measure of closeness of polynomial ()xp to a function ()xf. Approximations are often obtained by power series expansions in which the higher order terms are dropped.
Koo, Lee Feng
core   +1 more source

Some Newton’s inequalities on co-ordinates for Riemann–Liouville fractional integrals

Miskolc Mathematical Notes
In this paper, we give an identity involving Riemann–Liouville fractional integrals and partially differentiable function of two variables. Then, we use the newly established identity and prove some new Newton’s type inequalities for differentiable co ...
Fatih Hezenci, Tuba Tunç, Hüseyin Budak, Muhammad Aamir Ali   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Endomorphisms of Banach algebras of infinitely differentiable functions [PDF]

, 1999
In this note we study the endomorphisms of certain Banach algebras of infinitely differentiable functions on compact plane sets, associated with weight sequences M. These algebras were originally studied by Dales, Davie and McClure.
Kamowitz, Herbert, Feinstein, Joel
core  

Emulating non-differentiable metrics via knowledge-guided learning: Introducing the Minkowski image loss

Environmental Data Science
The “differentiability gap” presents a primary bottleneck in Earth system deep learning: Since models cannot be trained directly on non-differentiable scientific metrics and must rely on smooth proxies (e.g., MSE), they often fail to capture high ...
Filippo Quarenghi, Ryan Cotsakis, Tom Beucler   +2 more
doaj   +1 more source