Results 31 to 40 of about 24,433 (239)
MachinesAchieving precise prediction and intelligent control remains a pivotal challenge in cutting processes. This need is addressed through a comprehensive survey of three critical enabling technologies: cutting force/temperature modeling, tool path planning ...
Qingyang Jiang, Juan Song
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Darboux Transformations for Orthogonal Differential Systems and Differential Galois Theory [PDF]
, 2023 Darboux developed an ingenious algebraic mechanism to construct infinite chains of ''integrable'' second-order differential equations as well as their solutions.
Weil, Jacques-Arthur +3 more
core +2 more sources
Defence TechnologyThis paper proposes a distributed event-triggered control (ETC) framework to address cooperative target fencing challenges in UAV swarm. The proposed architecture eliminates the reliance on preset formation parameters while achieving multi-objective ...
Xiuxia Yang +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Multiscale Geometric Integration of Deterministic and Stochastic Systems [PDF]
, 2011 In order to accelerate computations and improve long time accuracy of numerical simulations, this thesis develops multiscale geometric integrators. For general multiscale stiff ODEs, SDEs, and PDEs, FLow AVeraging integratORs (FLAVORs) have been ...
Tao, Molei
core +1 more source
MathematicsBellows compensators are critical components in pipeline systems, designed to absorb thermal expansions, vibrations, and pressure reflections. Ensuring their operational reliability requires accurate prediction of the stress–strain state (SSS) and ...
Yerzhan Y. Sarybayev +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Geometric methods in deep learning [PDF]
, 2018 Derin öğrenme algoritmaları, son zamanlarda en yaygın kullanılan makine öğrenmesi yakla¸sımları haline gelmiştir. Derin öğrenmede geometrik metodların kullanılması ile makine öğrenmesi alanında dikkat çeken yakla¸sımlar ortaya çıkmıştır.
Özal Yildirim +3 more
core +1 more source