Results 61 to 70 of about 21,792 (245)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

On the solvability of a fourth order operator differential equations

Electronic Journal of Differential Equations, 2007
We establish sufficient conditions for the solvability of a fourth order operator differential equation. These conditions are expressed in terms of operator coefficients.
Ahmed Nouar
doaj  

On subclasses of analytic functions based on a quantum symmetric conformable differential operator with application

Advances in Difference Equations, 2020
Quantum calculus (the calculus without limit) appeared for the first time in fluid mechanics, noncommutative geometry and combinatorics studies. Recently, it has been included into the field of geometric function theory to extend differential operators ...
Rabha W. Ibrahim, Rafida M. Elobaid, Suzan J. Obaiys   +2 more
doaj   +1 more source

DEGENERATE FIRST ORDER DIFFERENTIAL-OPERATOR EQUATIONS

Proceedings of the YSU A: Physical and Mathematical Sciences, 2019
We consider boundary value problem for degenerate first order differentialoperator equation $Lu \mathclose{\equiv} t^{\alpha} u^{\prime} \mathclose{-} P u \mathclose{=} f $, $ u(0) \mathclose{-} \mu u(b) \mathclose{=} 0 $, where $ t \mathclose{\in} (0,b) $,  $ a \mathclose{\geq} 0 $, $ P: H \mathclose{\rightarrow} H $ is linear operator in separable ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Positive Solutions of Fractional Differential Equation with -Laplacian Operator

Abstract and Applied Analysis, 2013
The basic assumption of ecological economics is that resource allocation exists social optimal solution, and the social optimal solution and the optimal solution of enterprises can be complementary.
Teng Ren, Xiaochun Chen
doaj   +1 more source

Fractional Ulam-stability of fractional impulsive differential equation involving Hilfer-Katugampola fractional differential operator

Universal Journal of Mathematics and Applications, 2018
In this note, we set up existence, uniqueness as well as the stability of a special class of fractional differential equation (FDE) with Hilfer-Katugampola fractional differential operator (HKFDO). The outcomes are given by employing the Schaefer's fixed
Rabha Ibrahim, S. Harikrishnan, K. Kanagarajan   +2 more
doaj   +1 more source

Langevin equation in terms of conformable differential operators

Analele Universitatii "Ovidius" Constanta - Seria Matematica, 2020
Abstract In this paper, we establish sufficient criteria for the existence of solutions for a new kind of nonlinear Langevin equation involving conformable differential operators of different orders and equipped with integral boundary conditions.
Ahmad Bashir, Agarwal Ravi P., Alghanmi Madeaha, Alsaedi Ahmed   +3 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source