Results 181 to 190 of about 2,372,273 (212)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Effectiveness of Deep Brain Stimulation for Treatment-Resistant OCD: Systematic Review of Anatomical Targets and Meta-Analysis of Randomized and Non-Randomized Studies. [PDF]

Brain Sci
Dufault S, Potvin S, Patry S.
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Early Prosthetic Thrombosis After Transcatheter Tricuspid Valve Replacement: A Word of Caution. [PDF]

JACC Case Rep
Trinca F, Bousmaha N, Porterie J, Mohammadi S, Dumont E, M-Labbé B, O'Connor K, Poulin A, Rodès-Cabau J, Kalavrouziotis D.   +9 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Drought and Freezing Compromise Woody-Plant Functioning in High Mountain Ecosystems Under Mediterranean Climate: The Case of Bencomia exstipulata. [PDF]

Physiol Plant
Fernández-Marín B, Perera-Castro AV, Brito-Gutiérrez P, Arzac MI, Peña FJD, Ganthaler A, García-Rodríguez C, Laza JM, Luis VC, Hidalgo J, Mayr S, Neuner G, Ruiz-Medina MA, García-Plazaola JI, Puértolas J, González-Rodríguez ÁM.   +15 more
europepmc   +1 more source

Case Report: A case of myocardial calcification combined with abnormal Q waves on electrocardiogram. [PDF]

Front Cardiovasc Med
Li D, Huang Q, Situ X, Gao W, Li D.
europepmc   +1 more source

Transcaval SESAME, LAMPOON, and Valve-in-MAC: First Experience With SESAME Outside the United States. [PDF]

JACC Case Rep
Uttenthal F, Freeman P.
europepmc   +1 more source

Epicardial Lead Dysfunction in a Patient With Mechanical Tricuspid Valve-A Challenging Complication. [PDF]

Ann Noninvasive Electrocardiol
Guctekin T, Guctekin MY.
europepmc   +1 more source