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This 90-minute session seeks to provide a systematic framework for medical students relatively new to the differential diagnosis process. Via a combined lecture/case-based approach, the session presents basic clinical reasoning concepts and specific ...
Zev Waldman, Mary Ottolini
doaj +1 more source
XXXII. On the differential diagnosis of the plague bacillus from certain allied organisms [PDF]
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
DIFFERENTIAL DIAGNOSIS OF OPTIC NEURITIS [PDF]
: Optic neuritis is inflammation of the optic nerve, which in a single or repeated attacks can severely and permanently damage visual function. Errors in diagnostic are daily and usually occur because of incomplete diagnostic procedure performed.
Bukumiric Zoran+2 more
core +1 more source
THE DIFFERENTIAL DIAGNOSIS OF SYPHILIS AND PARASYPHILIS OF THE NERVOUS SYSTEM: Introduction to a Discussion on Syphilis and Parasyphilis of the Nervous System at the Medical Society of London on November 13th, 1911 [PDF]
F. W. Mott
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Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
wiley +1 more source
Endotracheal Metastasis Causing Airway Obstruction [PDF]
Endotracheal metastasis, a critical complication of primary lung cancer, is an extremely rare lesion. A 73-year-old woman who had previously received treatment for lung cancer presented to our emergency department with dyspnea.
Fujiwara, Takashi+2 more
core
Certain Aspects of the Differential Diagnosis between Epilepsy and Hysteria [PDF]
JAMES J. PUTNAM, George A. Waterman
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