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Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez+17 more
wiley +1 more source
Eccrine porocarcinoma of the head: An important differential diagnosis in the elderly patient [PDF]
Background: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations. Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in ...
Akiyoshi E+25 more
core +1 more source
Osteoblastoma of the femur in a patient with recurrent paronychia : case report [PDF]
Background: Osteoblastoma is a rare primary benign bone tumor that has varied radiologic presentation depending on the affected site. In selected cases, differential diagnosis with subacute osteomyelitis is necessary. Case Report: The authors present the
Babiak, Ireneusz+4 more
core
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
Differential diagnosis of iron deficiency [PDF]
Iron deficiency is considered to be the commonest hematological pathology in humans. Thus, the essential steps in an adequate approach of iron deficiency include: the proper identification of its causes and the differentiation between iron deficiency and
Figueiredo, Maria Stella, Vicari, Perla
core +1 more source
Ejaculate in Differential Diagnosis [PDF]
It is perhaps worth mentioning that examination of ejaculate can be helpful in the diagnosis of men with bronchiectasis of unknown origin: if they have cystic fibrosis, these patients usually have azoospermia, but unlike patients with Klinefelter syndrome they usually have testes of normal size.
openaire +3 more sources
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria+3 more
wiley +1 more source
THE DIFFERENTIAL DIAGNOSIS OF CHOLELITHIASIS. [PDF]
General Statement. —Gall stones were observed by Johann Kentman in 1565. They occur at all ages, having been observed in the newborn infant. Ten per cent. of all adult males,125 per cent, of all adult females2and 36 per cent, of the insane3have gall stones.
openaire +2 more sources
Seronegative spondyloarthropathies : a review : part I: classification and differential diagnosis [PDF]
The seronegative spondyloarthropathies comprise a group of non-rheumatoid disorders with similar clinical, laboratory and genetic features. Recognition of new clinical features has supported the notion that they all form part of a clinical spectrum ...
Borg, Andrew A.+2 more
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source