Results 71 to 80 of about 847,712 (307)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Differential diagnosis in sheep

, 2022
Differential diagnosis in sheep aims to be a practical, concise and user-friendly guide to the differential diagnosis, aetiology, laboratory diagnosis and medical disorders in sheep by covering the most relevant clinical disorders in sheep medical ...
Lacasta, Delia (Ed.), Quintas, Helder (Ed.), Ferrer, Luis Miguel (Ed.)   +2 more
core   +1 more source

Differential diagnosis of nonmelanoma pigmented skin lesions based on harmonic generation microscopy

, 2017
In vivo harmonic generation microscopy (HGM) has been applied successfully in healthy human skin and can achieve a submicron resolution, similar to histopathologic examination, even at a penetration depth up to 270 mu m.
Tsai, Ming-Rung;Cheng, Yu-Hsiang;Chen, Jau-Shiuh;Sheen, Yi-Shuan;Liao, Yi-Hua;Sun, Chi-Kuang, 廖怡華;陳昭旭;沈宜萱   +1 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential diagnosis of neonatal jaundice

Медицинский совет, 2016
Jaundice is one of the most common symptoms of the neonatal period which in most cases is not associated with a serious illness. For example, jaundice in healthy newborns which does not affect the child's development.
I. N. Zakharova, A. N. Goryainova, I. N. Kholodova, I. D. Мaikova, E. V. Belenovich, E. V. Tambieva, E. V. Bolbikova, A. N. Melen'kina, A. A. Khudyakov   +8 more
doaj   +1 more source

Radiomics-Guided Deep Learning Networks Classify Differential Diagnosis of Parkinsonism. [PDF]

The differential diagnosis between atypical Parkinsonian syndromes may be challenging and critical. We aimed to proposed a radiomics-guided deep learning (DL) model to discover interpretable DL features and further verify the proposed model through the ...
Wang, Luyao, Lu, Jiaying, Shi, Kuangyu, Shaoyou Wu, Ronghua Ling, Ping Wu, Jiang, Jiehui, Yan, Zhuangzhi, Liu, Yingqian, Min Wang, Yingqian Liu, Jiaying Lu, Juanjuan Jiang, Zuo, Chuantao, Ling, Ronghua, Wu, Shaoyou, Luyao Wang, Chuantao Zuo, Zhuangzhi Yan, Ge, Jingjie, Jiehui Jiang, Jingjie Ge, Wu, Ping, Jiang, Juanjuan, Wang, Min, Kuangyu Shi   +25 more
core   +1 more source

Physical Examination, Electrophysiological Procedures and Laboratory Tests Used to Differentially Diagnose Neuromuscular Disorders

, 2023
In the differential diagnosis of neuromuscular disorders, it is very important to know the family history of the patient, to perform a detailed physical examination, and to examine electrophysiological and biochemical analyses together.
Tiftikcioglu, Bedile Irem, Çolak, Ayfer
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Asthma: Differential Diagnosis and Comorbidities

Frontiers in Pediatrics, 2018
Childhood asthma remains a multifactorial disease with heterogeneous clinical phenotype and complex genetic inheritance. The primary aim of asthma management is to achieve control of symptoms, in order to reduce the risk of future exacerbations and ...
Nicola Ullmann, Virginia Mirra, Antonio Di Marco, Martino Pavone, Federica Porcaro, Valentina Negro, Alessandro Onofri, Renato Cutrera   +7 more
doaj   +1 more source