Results 91 to 100 of about 847,712 (307)

Differential diagnosis of throat pain

Медицинский совет, 2014
Sore throat is one of the most common reasons to see an ENT specialist or therapist. However, sore throat does not always mean tonsillitis or other inflammatory disease of the oropharynx. The practical value of the assumption, the author hopes, will help
I. B. Angotoeva
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. [PDF]

, 2012
The prevalence of Parkinson's disease (PD) increases with age. Up to 50% of PD show cognitive decline in terms of a mild cognitive impairment already in early stages that predict the development of dementia, which can occur in up to 80% of PD patients ...
Hans A Kretzschmar, Manuela Neumann, Hans A. Kretzschmar (46374), Neumann, Manuela, Soininen, H., Saskia Tawfik, Hengerer, B., Herukka, Sanna-Kaisa, Kulaksiz, H., Ferger, B., Tawfik, Saskia, Steinacker, Petra, Steinacker, P., Lenter, M., Manuela Neumann (120819), Jesse, S., Lehnert, S., Kulaksiz, Hasan, Bastian Hengerer, Neumann, M., Christine A F von Arnim, Markus Otto (120832), Otto, Markus, Christine A. F. von Arnim (120817), Lucilla Parnetti (120805), Sarah Jesse (120792), Parnetti, Lucilla, Hilkka Soininen, Jahn, Olaf, Wiltfang, Jens, Hilkka Soininen (120808), Jahn, O., Petra Steinacker (120812), Tumani, Hayrettin, Lenter, Martin, Kretzschmar, Hans A., Tumani, H., Otto, M., Boris Ferger, Hayrettin Tumani, Martin Lenter, Hengerer, Bastian, Saskia Tawfik (120814), Wiltfang, J., Olaf Jahn, Lucilla Parnetti, Soininen, Hilkka, Bastian Hengerer (120831), Sanna-Kaisa Herukka, Olaf Jahn (120801), Martin Lenter (120825), von Arnim, Christine A. F., Markus Otto, von Arnim, C., Stefan Lehnert, Petra Steinacker, Hayrettin Tumani (120815), Arnim, Christine A. F. von, Hasan Kulaksiz, Ferger, Boris, Stefan Lehnert (120797), Jens Wiltfang (44073), Sanna-Kaisa Herukka (120810), Jens Wiltfang, Kretschmar, H., Parnetti, L., Hasan Kulaksiz (120823), Boris Ferger (120827), Herukka, S., Jesse, Sarah, Tawfik, S., Lehnert, Stefan, Sarah Jesse   +72 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Challenges in the diagnosis of oral lichenoid lesions: a clinical case report [PDF]

RGO: Revista Gaúcha de Odontologia
The term oral lichenoid lesion is used to characterize a group of lesions which present clinical and histological characteristics similar to oral lichen planus, but that have a recognizable causal factor, the removal of which can lead to regression of ...
Érika Machado do Carmo Albuquerque, Letícia Albuquerque Rodrigues, Gislayne Nunes de Siqueira, Marcelo Bonifácio da Silva Sampieri, Filipe Nobre Chaves, Denise Hélen Imaculada Pereira de Oliveira   +5 more
doaj   +2 more sources

Differential diagnosis of eosinophilic oesophagitis variants and biomarker identification: current progress

Eosinophilic oesophagitis (EoE) is a disease characterized by dysregulated type 2 (T2) immune responses with enormous eosinophilic infiltration restricted to the oesophagus.
Marlena Tynecka, Aleksandra Roszko, Bartosz Hanczaruk, Kamil Kamiński   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Differential diagnosis between post-polio syndrome symptoms and temporomandibular disorder Clinical case

liomyelitis syndrome (PPS) is characterized by the delayed appearance of new neuromuscular symptoms in patients several years after their acute poliomyelitis paralysis.
Gustavo Augusto Seabra Barbosa, Maria Helena de Siqueira Torres Morais
core