Results 91 to 100 of about 10,510,537 (371)

Distributed Automatic Differentiation for Ptychography

Procedia Computer Science, 2017
Abstract Synchrotron radiation light source facilities are leading the way to ultrahigh resolution X-ray imaging. High resolution imaging is essential to understanding the fundamental structure and interaction of materials at the smallest length scale possible.
Tom Peterka, Youssef S. G. Nashed, Youssef S. G. Nashed, Chris Jacobsen, Chris Jacobsen, Junjing Deng   +5 more
openaire   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Nature Communications, 2016
Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally associated with the inhibition of gluconeogenesis and activation of lipogenesis.
N. Kubota, Tetsuya Kubota, E. Kajiwara, T. Iwamura, Hiroki Kumagai, Taku Watanabe, M. Inoue, Iseki Takamoto, Takayoshi Sasako, Katsuyoshi Kumagai, M. Kohjima, M. Nakamuta, M. Moroi, K. Sugi, T. Noda, Y. Terauchi, K. Ueki, T. Kadowaki   +17 more
semanticscholar   +1 more source

Numerical Approximation of Stationary Distribution for SPDEs [PDF]

, 2013
In this paper, we show that the exponential integrator scheme both in spatial discretization and time discretization for a class of stochastic partial differential equations has a unique stationary distribution whenever the stepsize is sufficiently small,
Bao, Jianhai, Yuan, Chenggui
core  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

W and Z precision physics

EPJ Web of Conferences, 2013
Recent results on W and Z physics from LHC experiments are presented. Measurements reviewed include total W and Z cross sections, W lepton charge asymmetry, and Z differential cross sections.
Isabel Josa M.
doaj   +1 more source

Effective macroscopic dynamics of stochastic partial differential equations in perforated domains

, 2006
An effective macroscopic model for a stochastic microscopic system is derived. The original microscopic system is modeled by a stochastic partial differential equation defined on a domain perforated with small holes or heterogeneities.
Allaire G., Brahim‐Otsmane S., Briane M., Cioranescu D., Cioranescu D., Daomin Cao, Jinqiao Duan, Maso G. D., Timofte C., Wei Wang, Zhikov V. V., Zhikov V. V.   +11 more
core   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source