Results 91 to 100 of about 965,307 (261)

Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain. [PDF]

iScience, 2023
Suk TR, Nguyen TT, Fisk ZA, Mitkovski M, Geertsma HM, Parmasad JA, Heer MM, Callaghan SM, Benseler F, Brose N, Tirard M, Rousseaux MWC.   +11 more
europepmc   +1 more source

Distributions for Compositionally Differentiating Parametric Discontinuities

Proceedings of the ACM on Programming Languages
Computations in physical simulation, computer graphics, and probabilistic inference often require the differentiation of discontinuous processes due to contact, occlusion, and changes at a point in time. Popular differentiable programming languages, such as PyTorch and JAX, ignore discontinuities during differentiation.
Jesse Michel, Kevin Mu, Xuanda Yang, Sai Praveen Bangaru, Elias Rojas Collins, Gilbert Bernstein, Jonathan Ragan-Kelley, Michael Carbin, Tzu-Mao Li   +8 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Differential cellulose distribution drives polarized growth of cotton fibers

Nature Communications
Plant cell morphogenesis relies on the mechanical properties of the primary cell wall, yet it remains unclear which components predominantly regulate wall extensibility.
Guangda Wang, Jie Wang, Huanhuan Yang, Jingxia Wu, Yanjun Yu, Xiaxia Zhang, Juan Tian, Yinping Ma, Gui-xian Xia, Yongbiao Xue, Staffan Persson, Lvwen Zhou, Zhaosheng Kong   +12 more
doaj   +1 more source

Differential Distribution of Brain Metastases from Non-Small Cell Lung Cancer Based on Mutation Status. [PDF]

Brain Sci, 2023
Chen BT, Jin T, Ye N, Chen SW, Rockne RC, Yoon S, Mambetsariev I, Daniel E, Salgia R.   +8 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Glycan-related genes in human gut microbiota exhibit differential distribution and diversity in carbohydrate degradation and glycan synthesis. [PDF]

Front Mol Biosci, 2023
Takihara H, Okuda S.
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Differential Distribution and Activity Profile of Acylpeptide Hydrolase in the Rat Seminiferous Epithelium. [PDF]

Biomedicines, 2022
Covarrubias AA, De la Fuente-Ortega E, Rossi G, Cocca E, Rossi M, Palmieri G, Pancetti FC.   +6 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source