Results 211 to 220 of about 965,307 (261)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

RETRACTION: LncRNA AATBC Regulates Pinin to Promote Metastasis in Nasopharyngeal Carcinoma

open access: yesMolecular Oncology, EarlyView.
RETRACTION: T. Tang, L. Yang, Y. Cao, M. Wang, S. Zhang, Z. Gong, F. Xiong, Y. He, Y. Zhou, Q. Liao, B. Xiang, M. Zhou, C. Guo, X. Li, Y. Li, W. Xiong, G. Li, and Z. Zeng, “LncRNA AATBC Regulates Pinin to Promote Metastasis in Nasopharyngeal Carcinoma,” Molecular Oncology 14, no. 9 (2020): 2251‐2270, https://doi.org/10.1002/1878‐0261.12703.
wiley   +1 more source

Periodic solutions in distribution for stochastic lattice differential equations

open access: yesElectronic Journal of Differential Equations
Yue Gao, Xue Yang
doaj  

Differentially Private Distributed Learning

INFORMS Journal on Computing, 2020
The rich data used to train learning models increasingly tend to be distributed and private. It is important to efficiently perform learning tasks without compromising individual users’ privacy even considering untrusted learning applications and, furthermore, understand how privacy-preservation mechanisms impact the learning process.
Yaqin Zhou, Shaojie Tang 0001
openaire   +2 more sources

Differentially Private Distributed Parameter Estimation

Journal of Systems Science and Complexity, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jimin Wang, Jianwei Tan, Ji-Feng Zhang
openaire   +1 more source

VERTICAL DIFFERENTIATION AND THE DISTRIBUTION OF INCOME

Bulletin of Economic Research, 2006
The paper analyses the effects of income concentration on the behaviour of a duopoly with vertical product differentiation and uncovered market. By using a trapezoid distribution, we solve explicitly for market equilibrium as a function of a mean preserving spread of the income distribution. We show that overall more concentrated incomes imply stronger
BENASSI, CORRADO, A. Chirco, C. Colombo
openaire   +4 more sources

Differentially Private Distributed Frequency Estimation

IEEE Transactions on Dependable and Secure Computing, 2023
Submitted/Accepted ...
Mengmeng Yang 0002   +4 more
openaire   +3 more sources

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