Results 101 to 110 of about 1,797,841 (315)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Existence of Solution to Nonlinear Third-Order Differential Equation and Iterative Method Utilization via Graph-Based Contraction

Mathematics
A new kind of graph-based contraction in a metric space is introduced in this article. We investigate results concerning the best proximity points and fixed points for these contractions, supported by illustrated examples.
Kanyuta Poochinapan, Sompop Moonchai, Tanadon Chaobankoh, Phakdi Charoensawan   +3 more
doaj   +1 more source

On the Use of the Differential Equation in Calculating the Results of Kinetic Measurements; the Reaction between Arsenic Acid and Potassium Iodide Near the Equilibrium [PDF]

, 1905
William C. Bray
openalex   +1 more source

On combinatorial differential equations

Journal of Mathematical Analysis and Applications, 1986
This article analyzes the solution set of a first order initial value differential problem of the form \(dy/dx=f(x,y)\), \(y(0)=0\) in the context of combinatorial species in the sense of A. Joyal. It turns out that many non-isomorphic combinatorial solutions are possible for a given problem, although they all have the same underlying generating series.
openaire   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Oscillation criteria for fractional impulsive hybrid partial differential equations

Проблемы анализа, 2019
In this paper, we study the oscillatory behavior of the solutions of fractional-order nonlinear impulsive hybrid partial differential equations with the mixed boundary condition.
Sadhasivam V., Deepa M.
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Optimizing second-order differential equation systems

Electronic Journal of Differential Equations, 2011
In this article we study some continuous versions of the Fletcher-Reeves iteration for minimization described by a system of second-order differential equations.
Tamas Hajba
doaj  

II.—A Fundamental Theorem regarding the Equivalence of Systems of Ordinary Linear Differential Equations, and its Application to the Determination of the Order and the Systematic Solution of a Determinate System of such Equations [PDF]

, 1897
George Chrystal
openalex   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source