Results 61 to 70 of about 297,552 (266)

Initial value problems of fractional order Hadamard-type functional differential equations

Electronic Journal of Differential Equations, 2015
The Banach fixed point theorem and a nonlinear alternative of Leray-Schauder type are used to investigate the existence and uniqueness of solutions for fractional order Hadamard-type functional and neutral functional differential equations.
Bashir Ahmad, Sotiris K. Ntouyas
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Fractional Differential Equations in Terms of Comparison Results and Lyapunov Stability with Initial Time Difference

Abstract and Applied Analysis, 2010
The qualitative behavior of a perturbed fractional-order differential equation with Caputo's derivative that differs in initial position and initial time with respect to the unperturbed fractional-order differential equation with Caputo's derivative has ...
Coşkun Yakar
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Transformation Method for Generating Periodic Solutions of Abel’s Differential Equation

Advances in Mathematical Physics, 2019
This paper deals with Abel’s differential equation. We suppose that r=r(t) is a periodic particular solution of Abel’s differential equation and, then, by means of the transformation method and the fixed point theory, present an alternative method of ...
Ni Hua
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

New applications of the two variable (G′/G, 1/G)-expansion method for closed form traveling wave solutions of integro-differential equations

Journal of Ocean Engineering and Science, 2019
Most fundamental themes in mathematical physics and modern engineering are investigated by the closed form traveling wave solutions of nonlinear evolution equations.
M. Mamun Miah, H.M. Shahadat Ali, M. Ali Akbar, Aly R. Seadawy   +3 more
doaj   +1 more source