Results 101 to 110 of about 442,456 (299)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

An Improved Differential Evolution Algorithm Based on Adaptive Parameter

open access: yesJournal of Control Science and Engineering, 2013
The differential evolution (DE) algorithm is a heuristic global optimization technique based on population which is easy to understand, simple to implement, reliable, and fast.
Zhehuang Huang, Yidong Chen
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Optimum manipulator path generation based on improved differential evolution constrained optimization algorithm

open access: yesInternational Journal of Advanced Robotic Systems, 2019
A new improved differential evolution constrained optimization algorithm is proposed to determine the optimum path generation of a rock-drilling manipulator with nine degrees of freedom.
Shimeng Fan, Xihua Xie, Xuanyi Zhou
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Coking energy consumption radial basis function prediction model improved by differential evolution algorithm

open access: yesMeasurement + Control, 2019
This paper presents a radial basis function prediction model improved by differential evolution algorithm for coking energy consumption process, which is very difficult to get online and real time because of the complex process. In the energy consumption
Wenhua Tao   +3 more
doaj   +1 more source

Differential Evolution Methods for the Fuzzy Extension of Functions [PDF]

open access: yes
The paper illustrates a differential evolution (DE) algorithm to calculate the level-cuts of the fuzzy extension of a multidimensional real valued function to fuzzy numbers.
Luciano Stefanini
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Design Optimization of Stewart-Gough Platform based on Differential Evolution Algorithm

open access: yesJixie chuandong, 2018
The Stewart-Gough platform is optimized by using the differential evolution algorithm. Firstly,the symmetric structure and unsymmetric structure of Stewart-Gough platform are introduced.
Wang Ting   +3 more
doaj  

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