Results 41 to 50 of about 80,774 (312)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A Reward Population-Based Differential Genetic Harmony Search Algorithm

Algorithms, 2022
To overcome the shortcomings of the harmony search algorithm, such as its slow convergence rate and poor global search ability, a reward population-based differential genetic harmony search algorithm is proposed.
Yang Zhang, Jiacheng Li, Lei Li
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

An Approximate Optimization Method for Solving Stiff Ordinary Differential Equations With Combinational Mutation Strategy of Differential Evolution Algorithm

Mendel, 2022
This paper examines the implementation of simple combination mutation of differential evolution algorithm for solving stiff ordinary differential equations.
Werry Febrianti, Kuntjoro Adji Sidarto, Novriana Sumarti   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Multi-Auv Distributed Task Allocation Based on the Differential Evolution Quantum Bee Colony Optimization Algorithm

Polish Maritime Research, 2017
The multi-autonomous underwater vehicle (AUV) distributed task allocation model of a contract net, which introduces an equilibrium coefficient, has been established to solve the multi-AUV distributed task allocation problem.
Li Jianjun, Zhang Ru Bo
doaj   +1 more source

Optimized Differential Evolution Algorithm for Software Testing

International Journal of Computational Intelligence Systems, 2018
Differential evolution (DE) algorithms for software testing usually exhibited limited performance and stability owing to possible premature-convergence-related aging during evolution processes.
Xiaodong Gou, Tingting Huang, Shunkun Yang, Mengxuan Su, Fuping Zeng   +4 more
doaj   +1 more source

A simple adaptive Differential Evolution algorithm [PDF]

2009 World Congress on Nature & Biologically Inspired Computing (NaBIC), 2009
Differential Evolution (DE) is a simple and efficient scheme for global optimization over continuous spaces. DE is generally considered as a reliable, accurate, robust and fast optimization techniques. It outperforms many other optimization algorithms in terms of convergence speed and robustness over common benchmark problems and real world ...
null Radha Thangaraj, null Millie Pant, null Ajith Abraham   +2 more
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source