Results 61 to 70 of about 88,991 (314)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Parameter Combination Framework for the Differential Evolution Algorithm [PDF]

Algorithms, 2019
The differential evolution (DE) algorithm is a popular and efficient evolutionary algorithm that can be used for single objective real-parameter optimization. Its performance is greatly affected by its parameters. Generally, parameter control strategies involve determining the most suitable value for the current state; there is only a little research ...
Jinghua Zhang, Ze Dong
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Neural network-based colonoscopic diagnosis using on-line learning and differential evolution [PDF]

, 2004
In this paper, on-line training of neural networks is investigated in the context of computer-assisted colonoscopic diagnosis. A memory-based adaptation of the learning rate for the on-line back-propagation (BP) is proposed and used to seed an on-line ...
Plagianakos, V.P., Vrahatis, M.N., Magoulas, George D.   +2 more
core   +1 more source

A Reward Population-Based Differential Genetic Harmony Search Algorithm

Algorithms, 2022
To overcome the shortcomings of the harmony search algorithm, such as its slow convergence rate and poor global search ability, a reward population-based differential genetic harmony search algorithm is proposed.
Yang Zhang, Jiacheng Li, Lei Li
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multi-Auv Distributed Task Allocation Based on the Differential Evolution Quantum Bee Colony Optimization Algorithm

Polish Maritime Research, 2017
The multi-autonomous underwater vehicle (AUV) distributed task allocation model of a contract net, which introduces an equilibrium coefficient, has been established to solve the multi-AUV distributed task allocation problem.
Li Jianjun, Zhang Ru Bo
doaj   +1 more source

Optimized Differential Evolution Algorithm for Software Testing

International Journal of Computational Intelligence Systems, 2018
Differential evolution (DE) algorithms for software testing usually exhibited limited performance and stability owing to possible premature-convergence-related aging during evolution processes.
Xiaodong Gou, Tingting Huang, Shunkun Yang, Mengxuan Su, Fuping Zeng   +4 more
doaj   +1 more source

An Adaptive Multiobjective Differential Evolution Algorithm

Journal of Computers, 2013
The mutation strategy and control parameter have a significant influence on the performance of differential evolution. An local and global mutation operator based subregion and external set strategies are proposed in this paper. They use the idea of direct simplex method of mathematical programming.
Fangqing Gu, Hai-Lin Liu 0001
openaire   +1 more source