Results 81 to 90 of about 184,630 (295)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Model reduction for analysis of cascading failures in power systems [PDF]

, 1999
In this paper, we apply a principal-orthogonal decomposition based method to the model reduction of a hybrid, nonlinear model of a power network. The results demonstrate that the sequence of fault events can be evaluated and predicted without necessarily
Lall, Sanjay, Lesieutre, Bernard C., Marsden, Jerrold E., Paganini, Fernando, Parrilo, Pablo A., Verghese, George C.   +5 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A proposed wavelet analysis based fault diagnosis scheme of power transformers using fault signatures and CT saturation

Results in Engineering
Diagnosis of concealed internal faults within power transformer is a key for high grid reliability to ensure continuity of power supply to customers. One of the urgent situations of power transformer is the faults under CT saturation and the operation ...
Amira M. Dahman, Adel A. Abou El-Ela, Mohamed I. Zaki, Ragab A. El Sehiemy   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Differential Fault and Algebraic Equation Combined Analysis on PICO

Mathematics
In modern information technology, research on block cipher security is imperative. Concerning the ultra lightweight block cipher PICO, there has been only one study focused on recovering its complete master key, with a large search space of 264, and no ...
Linxi Ding, Hongxin Zhang, Jun Xu, Xing Fang, Yejing Wu   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A new type of fault diagnosis method of asynchronous motor

Gong-kuang zidonghua, 2014
In view of problem of difficult parameters determination existed in fault diagnosis method of asynchronous motor based on RBF neural network, the paper proposed a fault diagnosis method of asynchronous motor based on RBF neural network optimized by ...
GOU Xijin, XU Jinxia, KONG Lili
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Adaptability analysis on differential protection of converter transformers in a VSC-HVDC transmission system connected to offshore wind farms

Zhejiang dianli
The fault characteristics of voltage source converter-based high voltage direct current （VSC-HVDC） transmission systems connected to offshore wind farms differ from those of conventional power systems.
CHENG Xiao, GU Qiaogen, REN Xuchao, ZHENG Chao, HUANG Tao, ZHANG Baoshun   +5 more
doaj   +1 more source