Results 51 to 60 of about 2,280,119 (299)
On The Foundations of Digital Games [PDF]
, 2013 Computers have lead to a revolution in the games we play, and, following this, an interest for computer-based games has been sparked in research communities.
Björk, Staffan, Bj\uf6rk, Staffan
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2016 We consider pursuit and evasion differential games of a group of m pursuers and one evader on manifolds with Euclidean metric. The motions of all players are simple, and maximal speeds of all players are equal.
Atamurat Kuchkarov +2 more
doaj +1 more source
Differential Terror Queue Games [PDF]
Dynamic Games and Applications, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Stefan Wrzaczek +4 more
openaire +5 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The abstract maximum principle and its application in the differential games theory
Научно-технический вестник информационных технологий, механики и оптикиThe problem of optimal control involving two opposing players is considered where optimality is understood in the minimax sense of achieving the best guaranteed outcome, and the control strategy is constructed with respect to the worst case admissible ...
A. A. Vedyakov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
EntropyUncertainty, time delays, and jumps often coexist in dynamic game problems due to the complexity of the environment. To address such issues, we can utilize uncertain delay differential equations with jumps to depict the dynamic changes in differential ...
Zhifu Jia
doaj +1 more source
A Differential Game with Exit Costs [PDF]
Dynamic Games and Applications, 2019 We study a differential game where two players separately control their own dynamics, pay a running cost, and moreover pay an exit cost (quitting the game) when they leave a fixed domain. In particular, each player has its own domain and the exit cost consists of three different exit costs, depending whether either the first player only leaves its ...
Fabio Bagagiolo +2 more
openaire +5 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source