Results 61 to 70 of about 3,335,914 (309)

A Differential Game with Exit Costs [PDF]

Dynamic Games and Applications, 2019
We study a differential game where two players separately control their own dynamics, pay a running cost, and moreover pay an exit cost (quitting the game) when they leave a fixed domain. In particular, each player has its own domain and the exit cost consists of three different exit costs, depending whether either the first player only leaves its ...
Fabio Bagagiolo, Rosario Maggistro, Marta Zoppello   +2 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Simple Motion Pursuit and Evasion Differential Games with Many Pursuers on Manifolds with Euclidean Metric

Discrete Dynamics in Nature and Society, 2016
We consider pursuit and evasion differential games of a group of m pursuers and one evader on manifolds with Euclidean metric. The motions of all players are simple, and maximal speeds of all players are equal.
Atamurat Kuchkarov, Gafurjan Ibragimov, Massimiliano Ferrara   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The abstract maximum principle and its application in the differential games theory

Научно-технический вестник информационных технологий, механики и оптики
The problem of optimal control involving two opposing players is considered where optimality is understood in the minimax sense of achieving the best guaranteed outcome, and the control strategy is constructed with respect to the worst case admissible ...
A. A. Vedyakov, A. O. Vedyakova, O. V. Slita, V. Yu. Tertychny-Dauri   +3 more
doaj   +1 more source

Differential game theory for versatile physical human–robot interaction

Nature Machine Intelligence, 2019
The last decades have seen a surge of robots working in contact with humans. However, until now these contact robots have made little use of the opportunities offered by physical interaction and lack a systematic methodology to produce versatile ...
Yanan Li, Gerolamo Carboni, Franck Gonzalez, D. Campolo, E. Burdet   +4 more
semanticscholar   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Equilibrium Control in Uncertain Linear Quadratic Differential Games with V-Jumps and State Delays: A Case Study on Carbon Emission Reduction

Entropy
Uncertainty, time delays, and jumps often coexist in dynamic game problems due to the complexity of the environment. To address such issues, we can utilize uncertain delay differential equations with jumps to depict the dynamic changes in differential ...
Zhifu Jia
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

On the Decomposition of Differential Game

CoRR
To understand the complexity of the dynamic of learning in differential games, we decompose the game into components where the dynamic is well understood. One of the possible tools is Helmholtz's theorem, which can decompose a vector field into a potential and a harmonic component.
Nanxiang Zhou, Jing Dong 0008, Yutian Li, Baoxiang Wang 0001   +3 more
openaire   +2 more sources