Results 51 to 60 of about 5,994 (211)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

Advanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li, Hao Liu, Yanbin Zhu, Hang Zhang, Qifeng Tao, Wenbo Zhao, Xin Miao, Shanshan Yang, Tianyu Chen, David Hunter, Changhai Ding, Ting Wang, Juan Wang, Wei Chen   +13 more
wiley   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

Intelligent Polymer Electrolytes for Next‐Generation Zinc‐Based Energy Storage Devices

Advanced Science, EarlyView.
Intelligent polymer electrolytes are organized into a three‐level hierarchy that advances zinc‐based energy storage from passive ion conduction toward active, adaptive, and intelligent operation. Molecular regulation of Zn+ coordination, water activity, desolvation, ion flux, and interfaces underpins adaptive self‐healing, anti‐freezing, adhesion, and ...
Sanath Kumar, Jhansirani Kesavan, Muhammad Asim, Atul Verma, Yen‐Pei Fu   +4 more
wiley   +1 more source

A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation

Advanced Energy Materials, EarlyView.
Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou, Cinthya Herrera, Duncan Atkins, Elixabete Ayerbe, Giorgio Baraldi, Stéphanie Belin, Anass Benayad, Didier Blanchard, Federico Capone, Ennio Capria, Isidora Cekic‐Laskovic, Robert Dominko, Kristina Edström, Ajay Gautam, Lukas Helfen, Antonella Iadecola, Quentin Jacquet, Gregor Kapun, Xinyu Li, Aleksandar Matic, Nataliia Mozhzhukhina, Andrew J. Naylor, Poul Norby, Chris O'Keefe, Alexandre Ponrouch, Jean‐Pascal Rueff, Elena Tchernykova, Deyana Tchitchekova, Israel Temprano, Nikita Vostrov, Marnix Wagemaker, Martin Winter, Christian Wölke, Tejs Vegge, Sandrine Lyonnard   +34 more
wiley   +1 more source

Separating Hydrogen Evolution From Electroplating in Zn Metal Batteries Using Scanning Electrochemical Microscopy

Advanced Energy Materials, EarlyView.
Operando SECM decouples hydrogen evolution from other degradation pathways in Zn metal batteries by quantifying its contribution during Zn electrodeposition. Although HER is shown to account for only a minor fraction of the irreversible charge loss, it remains a key indicator of interfacial evolution and by‐product formation governing cycling ...
J. T. Simon, Anna B. Gunnarsdóttir, Esther Lilian Gray, Debashis Tripathy, Farheen N Sayed, Manish Chhowalla, Stuart M. Clarke, Clare P. Grey, Svetlana Menkin   +8 more
wiley   +1 more source

Nanocrystalline LCO/LLZO Composite Cathode Films for Solid State Batteries

Advanced Energy Materials, EarlyView.
A single precursor solution is solution‐deposited and calcined at only 750°C to yield a dense, nanograined LiCoO2/LLZO composite cathode, in which both phases crystallize independently with minimal interdiffusion. Assembled into all‐solid‐state Li‐metal batteries, the composite delivers 111.7 mAh g−1 initial discharge capacity and retains 93% after 100
Lucie Quincke, Steffen Weinmann, Jesse J. Hinricher, Matteo Galasso, Chiara Althammer, Fran Kurnia, Kun Joong Kim, Wolff‐Ragnar Kiebach, Jennifer L. M. Rupp   +8 more
wiley   +1 more source

Continuous alternation: The complexity of pursuit in continuous domains

Algorithmica, 1993
J. Reif, S. Tate
semanticscholar   +1 more source

What Really Drives Agri‐Environment‐Climate Measures' Adoption? Mandatory Requirements, Behavioral Traits, and Structural Factors in the CAP Green Architecture

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT To increase farmer adoption of green practices, the EU Common Agricultural Policy includes both mandatory (conditionality) and voluntary instruments (eco‐schemes–ECS– and more demanding, multi‐annual agri‐environment‐climate measures –AECM–). Building on the experiment of Barreiro‐Hurle et al.
L. Sanchez‐Mata, M. Rodríguez‐Entrena, M. Espinosa‐Goded, F. J. Dessart, J. Barreiro‐Hurlé   +4 more
wiley   +1 more source

Voluntary Collective Action to Address Growing Agricultural Challenges in Two Countries: Experimental Insights and Commonalities

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We conducted two framed field economic experiments with citrus farmers in Florida, United States and soybean farmers in Argentina to investigate their willingness to coordinate pest and weed management efforts. Despite the contrast between these two agricultural contexts, we find striking behavioral commonalities.
Ariel Singerman, Sergio H. Lence
wiley   +1 more source