Results 121 to 130 of about 127,602 (284)

BV Solutions to Evolution Inclusion with a Time and Space Dependent Maximal Monotone Operator

Mathematics
This paper deals with the research of solutions of bounded variation (BV) to evolution inclusion coupled with a time and state dependent maximal monotone operator. Different problems are studied: existence of solutions, unicity of the solution, existence
Charles Castaing, Christiane Godet-Thobie, Manuel D. P. Monteiro Marques   +2 more
doaj   +1 more source

Superposition Principle for Differential Inclusions

, 2018
We prove an extension of the Superposition Principle by Ambrosio-Gigli-Savare in the context of a control problem. In particular, we link the solutions of a finite-dimensional control system, with dynamics given by a differential inclusion, to a solution of a continuity equation in the space of probability measures with admissible vector field.
Cavagnari G., Marigonda A., Piccoli B.
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Systems of Hemivariational Inclusions with Competing Operators

Mathematics
This paper focuses on a system of differential inclusions expressing hemivariational inequalities driven by competing operators constructed with p-Laplacians that involve two real parameters.
Dumitru Motreanu
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Existence of Solutions for w-Weighted ψ-Hilfer Fractional Differential Inclusions of Order μ ∈ (1, 2) with Non-Instantaneous Impulses in Banach Spaces

Fractal and Fractional
In this research, we obtain the sufficient conditions that guarantee that the set of solutions for an impulsive fractional differential inclusion involving a w-weighted ψ-Hilfer fractional derivative, D0,tσ,v,ψ,w,of order μ∈(1,2), in infinite dimensional
Zainab Alsheekhhussain, Ahmad Gamal Ibrahim, Mohammed Mossa Al-Sawalha, Yousef Jawarneh   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source