Results 111 to 120 of about 655,169 (388)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Determining Gender Differential Item Functioning for Mathematics in Coeducational School Culture

Malaysian Journal of Learning and Instruction, 2019
Purpose - In an attempt to explore item characteristics that behave differently between boys and girls, this comparative study examines gender Differential Item Functioning in a school culture that is noted to be ‘thriving’ mathematically ...
S. Kanageswari Suppiah Shanmugam
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Investigating the Impact of Item Parameter Drift for Item Response Theory Models with Mixture Distributions

Frontiers in Psychology, 2016
This study investigates the impact of item parameter drift (IPD) on parameter and ability estimation when the underlying measurement model fits a mixture distribution, thereby violating the item invariance property of unidimensional item response theory (
Yoon Soo ePark, Young-Sun eLee, Kuan eXing   +2 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

anchors: Software for Anchoring Vignette Data

Journal of Statistical Software, 2011
When respondents use the ordinal response categories of standard survey questions in different ways, the validity of analyses based on the resulting data can be biased.
Jonathan Wand, Gary King, Olivia Lau
doaj  

Evaluation of the psychometric properties of the family adaptability and cohesion scale (FACES III) through item response theory models in students from Chile and Colombia

BMC Psychology
Background A psychometric study of the Family Adaptability and Cohesion Scale (FACES III) has been conducted in Spanish-speaking countries from the perspective of the classical test theory.
Lindsey W. Vilca, Víctor Díaz-Narváez, Wilson Pastén Hidalgo, Nicolás Van Niekerk Bakit, Paula Moreno Reyes, Yaneth Herazo-Beltrán, Aura Gauna-Quiñonez, Alejandro Reyes-Reyes, Luz Marina Alonso Palacio, Marco Cervantes Mendoza   +9 more
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Funcionamento diferencial dos itens do Teste Cloze por Opção

Arquivos Brasileiros de Psicologia, 2011
This study analyzed the differential item functioning of Teste Cloze por Opção EM/U that assess collectively reading comprehension. The subjects were 489 students.
Maria Cristina Rodrigues Azevedo Joly, Nayane Martoni Piovezan   +1 more
doaj  

Impact of differential item functioning on item model fit using concurrent equating method

Large-scale Assessments in Education
This study aimed to evaluate the item model fit by equating the forms of the PISA 2018 mathematics subtest with concurrent common items equating in samples from Türkiye, the UK, and Italy.
Zeynep Uzun, Tuncay Öğretmen
doaj   +1 more source