Results 101 to 110 of about 4,433,555 (304)
المجلة الأردنية للعلوم التطبيقية-العلوم الانسانيةThis study aimed to examine the effectiveness of the Multiple Indicators Multiple Causes Model (MIMIC) in detecting differential item functioning of a test in relation to sample size and test length.
Reem Elyan, Yousef Sawalmeh
doaj +1 more source
Ethnic differential item functioning in the assessment of quality of life in cancer patients
Health and Quality of Life Outcomes, 2005 Background Past research has shown that Filipino cancer patients report lower levels of quality of life (QoL) than other ethnic groups. One possible explanation for this is that Filipinos do not define QoL in the same manner as others, resulting in bias ...
Gotay Carolyn C, Pagano Ian S
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Estimation of Item Response Models with the lmer Function from the lme4 Package in R [PDF]
In this paper we elaborate on the potential of the lmer function from the lme4 package in R for item response (IRT) modeling. In line with the package, an IRT framework is described based on generalized linear mixed modeling. The aspects of the framework
Ivailo Partchev +6 more
core
BMC Musculoskeletal Disorders, 2012 Background The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a widely used patient reported outcome in osteoarthritis. An important, but frequently overlooked, aspect of validating health outcome measures is to establish if ...
Pollard Beth +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Detecting Differential Item Functioning using Multiple-group Cognitive Diagnosis Models
, 2020 Detecting Differential Item Functioning using Multiple-group Cognitive Diagnosis ...
Wenchao Ma
core +1 more source
Use of differential item functioning (DIF) analysis for bias analysis in test construction
SA Journal of Industrial Psychology, 2004 When differential item functioning (DIF) item analysis procedures based on item response theory (IRT) are used during test construction, it is possible to draw item characteristic curves for the same item for different subgroups.
Marié De Beer
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source