Results 171 to 180 of about 656,712 (390)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Gender differential item functioning on a national field-specific test: The case of PhD entrance exam of TEFL in Iran [PDF]

Iranian Journal of Language Teaching Research, 2016
Differential Item Functioning (DIF) exists when examinees of equal ability from different groups have different probabilities of successful performance in a certain item.
Alireza Ahmadi, Ali Darabi Bazvand
doaj  

The Estimation of Item Response Models with the lmer Function from the lme4 Package in R [PDF]

In this paper we elaborate on the potential of the lmer function from the lme4 package in R for item response (IRT) modeling. In line with the package, an IRT framework is described based on generalized linear mixed modeling. The aspects of the framework
Abe Hofman, Francis Tuerlinckx, Ivailo Partchev, Marjan Bakker, Michel Nivard, Paul De Boeck, Robert Zwitser   +6 more
core   +1 more source

Measuring Moral Reasoning using Moral Dilemmas: Evaluating Reliability, Validity, and Differential Item Functioning of the Behavioral Defining Issues Test (bDIT) [PDF]

, 2019
We evaluated the reliability, validity, and differential item functioning (DIF) of a shorter version of the Defining Issues Test-1 (DIT-1), the behavioral DIT (bDIT), measuring the development of moral reasoning.
Choi, Youn-Jeng, Dawson, Kelsie J., Glenn, Andrea L., Han, Hyemin, Thoma, Stephen J.   +4 more
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Three factor differential item functioning analysis of a provincial final examination [PDF]

, 2003
Willy Edwin Chow
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Investigation of Theoretical Exams in Medical Faculties in Terms of Differential Item Functioning: Sample of Mersin University Medical Faculty

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014
Purpose: Current study investigated whether the measurement tools utilized during medical faculty preclinical period to form the basis of pass-fail decisions taken for students included Differential Item Functioning for foreign and Turkish students ...
Huseyin Selvi, Ibrahim Bashan, Gonul Aslan   +2 more
doaj  

lordif: An R Package for Detecting Differential Item Functioning Using Iterative Hybrid Ordinal Logistic Regression/Item Response Theory and Monte Carlo Simulations [PDF]

Logistic regression provides a flexible framework for detecting various types of differential item functioning (DIF). Previous efforts extended the framework by using item response theory (IRT) based trait scores, and by employing an iterative process ...
Laura E. Gibbons, Paul K. Crane, Seung W. Choi   +2 more
core   +1 more source