Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Examining differential item functioning and group differences across student and community samples on the Personality Inventory for the DSM-V-Short Form. [PDF]
van Zyl CJJ.
europepmc +1 more source
Differential Item Functioning of the Mini-BESTest Balance Measure: A Rasch Analysis Study. [PDF]
Caronni A +10 more
europepmc +1 more source
Detection of Differential Item Functioning in the Graded Response Model
Allan S. Cohen +2 more
openalex +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Differential item functioning in the children autism rating scale first edition in children with autism spectrum disorder based on a machine learning approach. [PDF]
Chen M, Peng K, Zhou L, Weng X.
europepmc +1 more source
Spanish Version of the Netherlands Empowerment List: Adaptation, Psychometric Validation, and Gender Differential Item Functioning Analysis [PDF]
Hernán María Sampietro +7 more
openalex +1 more source
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source

