Results 21 to 30 of about 60,378 (240)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
IEEE AccessA broadband waveguide-to-differential-line transition with a triple stacked patch is proposed for use in 300 GHz band. This transition consists of differential signal lines inserted into the waveguide region from both broad walls of the waveguide.
Chatchai Chokchai +4 more
doaj +1 more source
Differential geometry of line of curvature on parametric hypersurfaces in $\mathbb{E}^4$
, 2018 The purpose of this paper is, first, to give an algorithm that enables to obtain the lines of curvature on parametric hypersurfaces in Euclidean 4-space, and then, to obtain the curvatures of such lines by using the extended Darboux frame along the curve.
Çelik, Fatih, Düldül, Mustafa
openaire +2 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Timelike line congruences via surface theory in Minkowski 3-space
AIP AdvancesLine congruences are crucial in classical geometry, particularly in relating one surface to another through families of lines. These correspondences are most valuable when they preserve key geometric features of the original surface.
Areej A. Almoneef, Rashad A. Abdel-baky
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Acta Polytechnica, 2019 Differential equations of a relative material particle motion over the edge of an inclined flat ellipse that rotates around the axis of a vertical limiting cylinder have been deduced. The position of a plane relative to the axis of the rotation is set by
Serhii F. Pylypaka +3 more
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
On a subclass of ellipsoid complexes that admits a non-integral representation
Дифференциальная геометрия многообразий фигурUsing the group-theoretic method of differential geometric research by G. F. Laptev, as well as the methodology of scientific research on differential geometry by V. S.
M. V. Kretov, E. M. Kretova
doaj +1 more source