Results 51 to 60 of about 57,243 (286)

Differential geometry of line of curvature on parametric hypersurfaces in $\mathbb{E}^4$

, 2018
The purpose of this paper is, first, to give an algorithm that enables to obtain the lines of curvature on parametric hypersurfaces in Euclidean 4-space, and then, to obtain the curvatures of such lines by using the extended Darboux frame along the curve.
Çelik, Fatih, Düldül, Mustafa
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Railway Infrastructure Classification and Instability Identification Using Sentinel-1 SAR and Laser Scanning Data

Sensors, 2020
Satellite radar interferometry (InSAR) techniques have been successfully applied for structural health monitoring of line-infrastructure such as railway.
Ling Chang, Nikhil P. Sakpal, Sander Oude Elberink, Haoyu Wang   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Transmission Line Modeling of Vias in Differential Signals

, 2002
Signal layer transitions in differential lines are modeled using both FDTD and equivalent circuit methods. The equivalent circuit is developed based on transmission-line reasoning regarding via behavior.
Drewniak, James L., Fan, Jun, Smith, Norman W., Knighten, James L., Wang, Chen, Alexander, Ray   +5 more
core   +1 more source

On the discrete and continuous Miura chain associated with the sixth Painlev equation [PDF]

, 2000
A Miura chain is a (closed) sequence of differential (or difference) equations that are related by Miura or B\"acklund transformations. We describe such a chain for the sixth Painlev\'e equation (\pvi), containing, apart from \pvi itself, a Schwarzian ...
Hone, A. N. W., Nijhoff, F., Nijhoff, Frank W., Joshi, Nalini, Frank Nijhoff, Joshi, N., Nalini Joshi, Andrew Hone, Hone, Andrew N.W.   +8 more
core   +1 more source

指状锥面二次包络圆柱蜗杆传动接触线分析

Jixie chuandong, 2007
Based on differential geometry and spatial engaging theory,a set of formula of finger conical surface double enveloping worm gearing is derived.Through an example,the undercutting boundary line and contact line are depicted.At the same time,the variation
彭晓南, 王自兴
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source