Results 151 to 160 of about 3,685,749 (356)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Essential spectrum of elliptic systems of pseudo-differential operators on L² (RN) ⊕ L²(RN)
, 2017 Inspired by a result of Wong (Partial Differ Equ 13(10):1209–1221, 1988), we establish an analytic description of the essential spectrum of non-self-adjoint mixed-order systems of pseudo-differential operators on L² (RN) ⊕ L²(RN) that are uniformly ...
Orif O. Ibrogimov +3 more
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Theorems on the zeros of linear differential operators
Известия высших учебных заведений. Поволжский регион: Физико-математические наукиBackground. Differential connections between solutions of systems of differential equations play a significant role in mathematics and mathematical physics. The operators and algebras of differential symmetry of linear homogeneous systems of differential
A.I. Fomin, V.I. Titarenko
doaj +1 more source
On Differential and Antidifferential Operators
Моделирование и анализ информационных систем, 2011 On the basis of the operator approach to differentiation we extend the concept of an antiderivative notion to wider classes of functions.
A. N. Morozov
doaj
Mathematical model of Ebola and Covid-19 with fractional differential operators: Non-Markovian process and class for virus pathogen in the environment. [PDF]
Chaos Solitons Fractals, 2020 Zhang Z, Jain S.
europepmc +1 more source
Observables, maximal symmetric operators, POV measures and their applications in quantum mechanics
, 2015 Approximate observables, their description in terms of POV measures and the subsequent extension of the orthodox notion of observable are examined.
Fountain, Robert H.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
On boundary value problems for essentially loaded parabolic equations in bounded domains
Қарағанды университетінің хабаршысы. Математика сериясы, 2020 In the paper we study issues of a strong solution for "essentially" loaded differential equations of the parabolic type in bounded domains. Features of the problems under consideration: for example, in the L 2( Q ) space the corresponding differential ...
D.M. Akhmanova +2 more
doaj