Results 31 to 40 of about 10,735 (215)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Settlement Characteristics and Control Methods for Highway Widening Using Weak Expansive Soil
Applied SciencesIn highway widening projects, the wet–dry cycling effect of weakly expansive soil fill under seasonal groundwater fluctuations exacerbates differential settlement.
Senwei Wang +6 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Jurnal Teknik Sipil, 2005 This study presents the long-term measurements of traffic load induced settlement of pavement surface in Saga airport highway, Japan. In addition, the subground characteristics of the deposit were discussed in associated with their typical properties ...
Lawalenna Samang +2 more
doaj +1 more source
Adaptive Optimization Method for Piled Raft Foundations Based on Variable Pile Spacing
Applied Sciences, 2023 Stricter control of the differential settlement is always required in important buildings more than in ordinary buildings. It becomes a necessity to find a simple and efficient optimum design method for pile foundations in terms of performance and ...
Chenyang Yuan, Yunfei Xie, Mang Ou
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Centrifugal test on influence of widening styles on the engineering characteristics of soft soil
Shuiwen dizhi gongcheng dizhi, 2022 Compatibility of deformation between the existing embankment and widened portion is a common problem in widening projects. There is still a lack of direct comparative analysis of the influence of widening methods on the engineering characteristics of ...
Guanbao YE +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source