Results 51 to 60 of about 10,735 (215)

Parametric Modelling and Nonlinear FE Analysis of Trepponti Bridge Subjected to Differential Settlements

Buildings
The Trepponti bridge in Comacchio (Italy) is a significant masonry landmark characterised by a complex geometry. Its structure comprises five irregularly connected segments, creating pronounced geometric discontinuities.
Giovanni Meloni, Mohammad Pourfouladi, Natalia Pingaro   +2 more
doaj   +1 more source

Optimization Method for Irregular Piled Raft Foundation on Layered Soil Media

Advances in Civil Engineering, 2019
Important buildings such as nuclear power plants always require stricter control of differential settlement than ordinary buildings. Therefore, it is necessary to provide an optimized design for the piled raft foundations of important buildings.
Yunfei Xie, Shichun Chi
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Settlement Characteristics and Control Parameters for the Integrated Construction of Large-Section Underground Structures and Airport Terminals: A Case Study

Buildings
Settlement control for tunnel–terminal co-construction projects remains undefined, despite the growing trend of integrating multiple transportation modes within large-scale transport hubs.
Rongzhen Zhang, Wei Liu, Zekun Wei, Jianyong Han, Guangbiao Shao, Shenao Li   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Deformation behaviors and variable rigidity design with equilibrium settlement for CFG pile composite foundation of large storage tanks

Yantu gongcheng xuebao, 2018
The foundation of large storage tanks has requirements of large bearing capacity and limited differential settlement. Because the natural foundation generally cannot meet the requirements of bearing capacity and deformation, it needs to be treated. It is
LI Ji-cai 1, 2, LI Neng-hui 1, CONG Jian 1, CAO Yong-lang 1, CAO Jun 1, 2
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Deformation monitoring of building foundations by hydrostatic leveling

Инженерно-строительный журнал, 2015
When arranging a deformation monitoring system for a building, it is important to control the deformation state of its foundations. Various methods to control the deformation state of a building foundation include the method of hydrostatic leveling ...
V.V. Yepin, R.V. Tsvetkov, I.N. Shardakov   +2 more
doaj   +1 more source