Results 91 to 100 of about 340,748 (309)

Digital Holographic Microscopy in Veterinary Medicine—A Feasibility Study to Analyze Label-Free Leukocytes in Blood and Milk of Dairy Cows

Animals
For several years, the determination of a differential cell count of a raw milk sample has been proposed as a more accurate tool for monitoring the udder health of dairy cows compared with using the absolute somatic cell count.
Sabine Farschtschi, Manuel Lengl, Stefan Röhrl, Christian Klenk, Oliver Hayden, Klaus Diepold, Michael W. Pfaffl   +6 more
doaj   +1 more source

Can We Detect Mastitis earlier than Farmers? [PDF]

arXiv, 2020
The aim of this study was to build a modelling framework that would allow us to be able to detect mastitis infections before they would normally be found by farmers through the introduction of machine learning techniques. In the making of this we created two different modelling framework's, one that works on the premise of detecting Sub Clinical ...
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure. [PDF]

, 2020
The development of an in vitro system in which human primordial germ cell-like cells (hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable to further our understanding of human primordial germ cell (hPGC) specification ...
Bower, Grace, Chialastri, Alex, Clark, Amander T, Dey, Siddharth S, Gell, Joanna J, Hancock, Grace, Liu, Wanlu, Sosa, Enrique, Tao, Yu, Wamaitha, Sissy E   +9 more
core  

Preinfection in vitro chemotaxis, phagocytosis, oxidative burst, and expression of CD11/CD18 receptors and their predictive capacity on the outcome of mastitis induced in dairy cows with Escherichia coli. [PDF]

, 1997
Four to 6 wk after parturition, 12 cows in second, fourth, or fifth lactation were experimentally infected in one gland with Escherichia coli. The capacity of chemotaxis, phagocytosis, oxidative burst, and expression of CD11/CD18 receptors to predict the
A. Brand, A.J.J.M. Daemen, Arfors, Burton, Burvenich, C. Burvenich, Cai, Caroll, Chenoweth, E.N. Noordhuizen-Stassen, Gelfand, Gilbert, Heyneman, Hill, Kehrli, Kehrli, Kremer, Lohuis, Myllys, Nagahata, Paape, Rainard, Saad, Schukken, Shuster, Simpson, Smith, Splitter, T. Van Werven, van Werven, Y.H. Schukken   +30 more
core   +2 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

DNA Torsion-based Model of Cell Fate Phase Transitions [PDF]

arXiv, 2020
All stem cell fate transitions, including the metabolic reprogramming of stem cells and the somatic reprogramming of fibroblasts into pluripotent stem cells, can be understood from a unified theoretical model of cell fates. Each cell fate transition can be regarded as a phase transition in DNA supercoiling.
arxiv  

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +1 more source

A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia [PDF]

, 2016
We report the findings from a patient who presented with a concurrent mediastinal germ cell tumor (GCT) and acute myeloid leukemia (AML). Bone marrow pathology was consistent with a diagnosis of acute megakaryoblastic leukemia (AML M7), and biopsy of an ...
Demeter, Ryan T, Duncavage, Eric J, Griffith, Malachi, Griffith, Obi L, Hagemann, Ian S, Lu, Charles, Magrini, Vincent, Miller, Christopher A, O\u27Laughlin, Michelle, Ozenberger, Bradley A, Riedell, Peter, Wartman, Lukas D, Westervelt, Peter   +12 more
core   +2 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source