Results 91 to 100 of about 6,704,072 (257)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Differential expression analysis for sequence count data [PDF]

, 2010
*Motivation:* High-throughput nucleotide sequencing provides quantitative readouts in assays for RNA expression (RNA-Seq), protein-DNA binding (ChIP-Seq) or cell counting (barcode sequencing).
Simon Anders, Wolfgang Huber, Klawonn, Frank   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. [PDF]

, 2012
BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load.
S. Matheron, M. Sharland, Niels Obel (135891), R. Thiebaut, Jesper Grarup (453101), José M Miro, Reiss, Peter, Furrer, H, D. Haerry, A. Cozzi Lepri, Josefa Muñoz (11702276), Miró Meda, José M. (José María), 1956-, Hansjakob Furrer (93994), Ole Kirk (314889), Gazzard, B, G. Touloumi, Raffi, F, Josefa Muñoz, J. Reekie, A. Castagna, G. Fatkenheuer, R. Lodwick, Niels Obel, Sophie Grabar (697347), S. Grabar, T. Goetghebuer, J. Grarup, The Opportunistic Infections Project Team of the Collaboration o (16174457), D. Gibb, A. Antinori, Peter Reiss (4933), E. Girardi, José M Miro (16174463), Raffi, Francois, Antonella Castagna (255402), Grarup, Jesper, F. Engsig, Peter Reiss, Kirk, Ole, F. Gutierrez, Opportunistic Infections Project Team of the Collaboration of Ob,, H. Furrer, J. Casabona, M. Egger, O. Lambotte, Sylvie Ayayi (16174460), J. Ghosn, V. Bouteloup, Obel, N, Young, Jim, De Wit, Stéphane, Chêne, Geneviève, Heiner Bucher, M. Psichogiou, Mina Psichogiou (146065), Y. Young, C. Stephan, Chêne, G, Martin Fisher (300134), C. Lewden, A. D’Arminio Monforte, Ayayi, Sylvie, R. Zangerle, Young, J, S. De Wit, Laurence Meyer (130347), Bucher, Heiner, Antonella Castagna, Miró, José María, Geneviève Chêne, C. Sabin, Meyer, Laurence, Félix Gutierrez, Miro, José M, P. Morlat, P. Tookey, C. Torti, Gazzard, Brian, R. Paredes, Miro, José M., The Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord (614233), J. M. Miro, V. Le Moing, I. Weller, Francois Raffi, A. Mocroft, C. Smit, Jim Young (252690), S. Ayayi, Grarup, J, Jesper Kjaer, Sharland, M, Brian Gazzard, M. Prins, J. Warszawski, A. Noguera Julian, M. Garrido, De Wit, S, F. de Wolf, H. Bucher, Muñoz, J, J. Miro, C. Thorne, O. Kirk, Francois Raffi (6269708), Stéphane De Wit, Jesper Grarup, Gutierrez, Félix, J. Kjaer, Kjaer, J, J. Munoz, Bucher, Heiner H.C., Ole Kirk, V. von Wyl, C. Leport, A. Scherrer, L. Galli, Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord, Kjaer, Jesper, D. Costagliola, J. Sterne, Sophie Grabar, Opportunistic Infections Project Team of the Collaboration of Ob, P. Reiss, F. Dabis, Heiner Bucher (3510056), Meyer, L, A. Antoniadou, Furrer, Hansjakob, Jim Young, J. Ramos, J. Bohlius, A. Phillips, Hansjakob Furrer, Noguera Julian, Antoni, Sylvie Ayayi, Collaboration of Observational HIV Epidemiological Research Europe (COHERE), Castagna, A, Geneviève Chêne (252698), Ayayi, S, Obel, Niels, C. Colin, Bucher, H, F. Raffi, R. Teira, Jesper Kjaer (453100), Castagna, Antonella, Psichogiou, M, L. Meyer, N. Brockmeyer, A. Rauch, G. Chene, Miro, JM, Grabar, Sophie, M. Puoti, Kirk, O, Laurence Meyer, Reekie, Joanne ; https://orcid.org/, Muñoz, Josefa, B. Gazzard, N. Obel, M. M. Krause, J. Del Amo, Mina Psichogiou, L. Wittkop, M. Battegay, Grabar, S, Stéphane De Wit (262489), Brian Gazzard (4921), M. Fisher, Reiss, P, Gutierrez, F, S. Perez Hoyos, M. Dorrucci, Mike Sharland (258810), M. Paulsen, B. Ledergerber, Mike Sharland, Sharland, Mike, Psichogiou, Mina, C. Mussini, Félix Gutierrez (379459), Miró Meda, José M., COHERE EuroCoord European AIDS Treatment Grp   +183 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Merging and characterising phenotypic data on conventional and rare traits from dairy cattle experimental resources in three countries [PDF]

, 2012
peer-reviewedThis study set out to demonstrate the feasibility of merging data from different experimental resource dairy populations for joint genetic analyses.
Coffey, M.P., Veerkamp, Roel F., Coffey, M. P., Veerkamp, RF, Berry, D.P., Berry, D. P., Berry, DP, Wall, E; id_orcid, Wall, E., Veerkamp, R.F., Coffey, Mike P., Veerkamp, R. F., Coffey, MP, Banos, G., Banos, G; id_orcid, Berry, Donagh   +15 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source