Results 171 to 180 of about 2,938,585 (308)

Quality improvement package for severe tuberculosis triage in Tamil Nadu, India. [PDF]

Public Health Action
Jeyakumar A, Kalaiselvi S, Nair D, Vijayaprabha R, Gayathri K, Kabir D, Melfha JM, Bhatnagar T, Srinivasan R, Balusamy M, Shanmugasundaram S, Catherine A, Nithya N, Venkateshwar R, Frederick A, Shewade HD.   +15 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The HMG-CoA Reductase Inhibitor Fluvastatin Promotes Th2-Skewed Immune Responses by Modulating Dendritic Cell Differentiation. [PDF]

Genes Cells
Ishikawa S, Mizuno H, Murase K, Sasano K, Ogawa I, Itoh Y, Itoh S, Hida S.   +7 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Detection of Residual Pluripotent Stem Cells in Differentiated Cells-General Requirements for Probe-Based Quantitative PCR Assay. [PDF]

Cell Prolif
Cao J, Xu R, Fu B, Yu J, Na T, Ma A, Hao J, Wang L, Zhao H, Wei Q, Rao C, Wang H, Yang Z, Zhang Y, Zheng Z, Li Q, Zhang W, Chen Q, Hu S, Zhou L, Fan J, Sun S, Xie J, Li C, Zhang T, Gan Y, Wang S, Stacey GN, Wei J, Zhao T, Zhang YA.   +30 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers, Part II: Follow-up Surveillance after Initial Treatment 2026. [PDF]

Endocrinol Metab (Seoul)
Lee EK, Kang SH, Koo BS, Kim M, Kim MJ, Kim BH, Kim JW, Na DG, Park S, Bang JI, Back K, Seo Y, Son YI, Song YS, Shin DY, Ahn JH, Ahn HY, Oh SW, Won HR, Yoo WS, Lee MK, Lee SW, Lee J, Lee JY, Lim DJ, Chung KW, Chong A, Jung JH, Cho SW, Cho YY, Hong CM, Park YJ, Korean Thyroid Association Guideline Committee on the Management of Thyroid Nodule and Cancer.   +32 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Variability in Intravenous Insulin Infusion Management in Italian Intensive Care Units: A National Cross-Sectional Survey of Reported Nursing Practice. [PDF]

Nurs Crit Care
Pujia C, Neri G, Mastrangelo H, Mazza G, Biamonte E, Mercuri C, Bosco V, Montalcini T, Garofalo E.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source