Results 101 to 110 of about 101,301 (304)

The Difference in Thyroid Stimulating Hormone Levels between Differentiated Carcinoma and Benign Enlargement

International Archives of Otorhinolaryngology, 2020
Introduction Papillary and follicular thyroid carcinoma are common head and neck cancers. This cancer expresses a thyroid stimulating hormone (TSH) receptor that plays a role as a cancer stimulant substance.
Bambang Udji Djoko Rianto, Anton Sony Wibowo, Camelia Herdini   +2 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

A taxonomy of epithelial human cancer and their metastases [PDF]

, 2009
Background: Microarray technology has allowed to molecularly characterize many different cancer sites. This technology has the potential to individualize therapy and to discover new drug targets.
Olivier Gevaert, Anneleen Daemen, Bart De Moor, Louis Libbrecht, CH Chung, TR Golub, B Weigelt, T Sorlie, DN Hayes, CM Perou, A Bhattacharjee, A Alizadeh, T Sorlie, S Ramaswamy, TJ Giordano, D Rhodes, S Ramaswamy, GV Glinsky, N Pavlidis, RW Tothill, RA Bender, G Bloom, XJ Ma, D Talantov, CL Wilson, M Dai, A Subramanian, G Dennis, DW Huang, PS Nelson, M Cuatrecasas, JH Eichhorn, SK Tickoo, G Ayala, J Brugarolas, P Staller, X Liu, BJ Yoder, M Lacroix, B Weigelt, C Sotiriou, EA Rakha, C Sotiriou, AV Ivshina, M Ignatiadis, JX Yu, Z Hu, EK Sloan, AK Witkiewicz, L Lukes, AK Witkiewicz, XJ Ma, K Pavlakis, S Troup, K Wennmalm, P Schedin, G Finak, KA Oien, HG Laberke, MB Amin, SJ Jung, RC Bast Jr, JD Seidman, H Kang, H Naora, SM Smorenburg, T Sukata, IJ Matouk, S Khambata-Ford, MA Pantaleo, DH Ki, A Ramasamy, M Snyder, J Belmont, K Chin, LD Miller, J Pittman   +76 more
core   +3 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]

, 2016
Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca, Lanza, Rosina, Lunardi, Gianluigi, Menghi, Antonello, Pecorella, Irene, Rossi, Lorena, Scarpa, Susanna, Sini, Valentina   +7 more
core  

Thyroid nodules and differentiated thyroid cancer: Brazilian consensus [PDF]

, 2007
Thyroid nodules are a common manifestation of thyroid diseases. It is estimated that ~10% of adults have palpable thyroid nodules with the frequency increasing throughout life.
Carvalho, Gisah A., Graf, Hans, Maciel, Léa M. Zanini, Maciel, Rui Monteiro de Barros, Maia, Ana Luiza, Rosário, Pedro W., Vaisman, Mario, Ward, Laura S.   +7 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]

, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Anren Kuang, Da Mu, Rui Huang, Suping Li, Xiaojuan Ma   +4 more
core   +1 more source

Thyroid ultrasonography reporting: consensus of Italian Thyroid Association (AIT), Italian Society of Endocrinology (SIE), Italian Society of Ultrasonography in Medicine and Biology (SIUMB) and Ultrasound Chapter of Italian Society of Medical Radiology (SIRM) [PDF]

, 2018
Thyroid ultrasonography (US) is the gold standard for thyroid imaging and its widespread use is due to an optimal spatial resolution for superficial anatomic structures, a low cost and the lack of health risks.
Cantisani, V., Chiovato, L., Durante, C., Farina, R., Frasoldati, A., Garberoglio, R., Ianni, F., Pontecorvi, A., Rago, T., Spiezia, S., Vallone, G., Vitti, P.   +11 more
core   +1 more source