Results 91 to 100 of about 101,301 (304)

Predicting risk of malignancy in patients with indeterminate thyroid nodules [PDF]

, 2018
Thyroid cancer is the most prevalent endocrine cancer (1). The prevalence of palpable thyroid nodules in the general adult population is 4% to 7% (2). Ultrasound imaging detects thyroid nodules in 19%-68% of randomly selected individuals (3). The rate of
Carnes, Nicholas
core  

Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer—the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis [PDF]

, 2014
Increased glucose uptake mediated by glucose transporters and reliance on glycolysis are common features of malignant cells. Hypoxia-inducible factor-1α supports the adaptation of hypoxic cells by inducing genes related to glucose metabolism.
Anna Krześlak, AP Demasi, AW Eckert, AW Eckert, BW Kim, C Zhang, CM Douglas, DE Burstein, DW Li, E Cadman, Ewa Brzezińska-Błaszczyk, Ewa Forma, FR Ayala, GL Semenza, H Kaida, H Kaida, Iwona Lewy-Trenda, J Xie, JL Roh, JL Thorne, K Müssig, K Starska, Katarzyna Starska, L Lan, L Zhang, M Kobayashi, M Mueckler, M Shimanishi, Magdalena Bryś, ML Schrijvers, O Koperek, OJ Kwon, Paweł Jóźwiak, R Cabanillas, R Ciampi, R Rashmi, S Kondo, S Ohba, S Zhou, SB Edge, SW Jing, SX Yan, T Yamada, W Fenske, W Ping, X Zhang, XH Chen, XH Wu, XP Sun, Y Cui, Y Kondo, YY Xu   +51 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Lenvatinib exhibits antineoplastic activity in anaplastic thyroid cancer in vitro and in vivo [PDF]

, 2018
Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor (TKI) of VEGFR1-VEGFR3, FGFR1-FGFR4, PDGFRα, RET and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) signaling networks involved in tumor angiogenesis.
Antonelli, Alessandro, Baldini, Enke, Bocci, Guido, Di Desidero, Teresa, Elia, Giusy, Fallahi, Poupak, Ferrari, Silvia Martina, Materazzi, Gabriele, Miccoli, Paolo, Motta, Concettina La, Orlandi, Paola, Paparo, Sabrina Rosaria, Patrizio, Armando, Piaggi, Simona, Ragusa, Francesca, Ruffilli, Ilaria, Ulisse, Salvatore   +16 more
core   +2 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Management of follicular thyroid carcinoma

European Thyroid Journal
Follicular thyroid carcinoma (FTC) is the second most common histological type of thyroid carcinoma. This review aims to summarize the available evidence and guidelines and provide an updated consensus regarding the management of FTC.
Haruhiko Yamazaki, Kiminori Sugino, Ryohei Katoh, Kenichi Matsuzu, Wataru Kitagawa, Mitsuji Nagahama, Aya Saito, Koichi Ito   +7 more
doaj   +1 more source

Is thyroid nodule location associated with malignancy risk? [PDF]

, 2019
PURPOSE: Nodules located in the upper pole of the thyroid may carry a greater risk for malignancy than those in the lower pole. We conducted a study to analyze the risk of malignancy of nodules depending on location.
Biffoni, Marco, Ciotti, Laura, Durante, Cosimo, Falcone, Rosa, Giacomelli, Laura, Grani, Giorgio, Lamartina, Livia, Lomonaco, Cristiano, Maranghi, Marianna, Ramundo, Valeria   +9 more
core   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Interobserver agreement of Thyroid Imaging Reporting and Data System (TIRADS) and strain elastography for the assessment of thyroid nodules [PDF]

, 2013
Background: Thyroid Imaging Reporting and Data System (TIRADS) was developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules.
Berner, Christian, Bogdanou, Dimitra, Bojunga, Jörg, Dauth, Nina, Friedrich-Rust, Mireen, Herrmann, Eva, Meyer, Gesine, Zeuzem, Stefan   +7 more
core   +2 more sources

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source