Results 91 to 100 of about 3,508,804 (299)

Quality of life in differentiated thyroid cancer

International Journal of Surgery, 2018
The incidence of thyroid cancer has increased significantly over the last ten years and conversely the mortality has decreased. With 85% of patients with thyroid cancer surviving for ten years or longer it is increasingly important to study the quality of life in these patients and identify which aspects of the patients' health and wellbeing could be ...
Charlotte McIntyre, Thomas Jacques, Fausto Palazzo, Kate Farnell, Neil Tolley   +4 more
openaire   +2 more sources

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

Differentiated Thyroid Cancer: A Health Economic Review

, 2021
The incidence of differentiated thyroid cancer (DTC) is rising, mainly because of an increased detection of asymptomatic thyroid nodularity revealed by the liberal use of thyroid ultrasound.
Klaas Van Den Heede, Neil S. Tolley, Fausto F. Palazzo, Aimee N. Di Marco   +3 more
core   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

The correlation study between the glucose metabolism of 18F-FDG PET/CT incidental thyroid cancer and clinicopathologic characteristics

Zhongguo aizheng zazhi, 2016
Background and purpose: The proportion of incidental thyroid cancer in PET imaging was significantly increased with the wide application of 18F-FDG PET/CT.
李雪娜, 尹雅芙, 杜补林
doaj  

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Unusual Presentation of Differentiated Thyroid Cancer Metastasis

International Archives of Otorhinolaryngology, 2018
Introduction The rates of thyroid cancers are on a rise, especially well-differentiated thyroid cancers. This could be partly due to newer diagnostic modalities, like high-resolution ultrasound, that can pick up smaller lesions.
Haissan Iftikhar, Mubasher Ikram, Adnan Yar Muhammad, Karim Rizwan Nathani   +3 more
doaj   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Insulin-like Growth Factor-I and Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition

, 2014
Background: Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and antiapoptotic properties. Methods: This study prospectively investigated the
Tjonneland, Anne, Chirlaque, Maria-Dolores, Agudo, Antonio, Lagiou, Pagona, Weiderpass, Elisabete, Travis, Ruth C., Khaw, Kay-Tee, Sandström, Maria,, Bueno-de-Mesquita, H Bas, Key, Timothy J., Trichopoulou, Antonia, Lund, Eiliv, Peeters, Petra H M, Tsilidis, Konstantinos K., Palli, Domenico, Romieu, Isabelle, Riboli, Elio, Tipper, Sarah J, Lukanova, Annekatrin,, Tumino, Rosario, Allen, Naomi E, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Tipper, Sarah J., Key, Timothy J, Almquist, Martin,, Rinaldi, Sabina, Tsilidis, Konstantinos K, Ardanaz, Eva, Lund University., Kaaks, Rudolf, Hennings, Joakim, Krogh, Vittorio, Panico, Salvatore, Zanetti, Roberto, Lukanova, Annekatrin, Schmidt, Julie A, Mesrine, Sylvie, Wareham, Nick, Menendez, Virginia, Franceschi, Silvia, Hennings, Joakim,, Trichopoulos, Dimitrios, Overvad, Kim, Sanchez, Mara-Jose, Tjønneland, Anne, Schmidt, Julie A., Allen, Naomi E., Boutron-Ruault, Marie-Christine, Sandstrom, Maria, Sanchez, Maria-Jose, Wareham, Nicholas, Travis, Ruth C, Dossus, Laure, Larranaga, Nerea, Almquist, Martin, Boeing, Heiner, Gunter, Marc J., Gunter, Marc J   +58 more
core   +1 more source