Results 71 to 80 of about 101,301 (304)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma

International Journal of Endocrinology, 2015
ATM and γH2AX play a vital role in the detection of DNA double-strand breaks (DSB) and DNA damage response (DDR). This study aims to investigate ATM and γH2AX expression in thyroid cancer and discuss possible relationship between thyroid function tests ...
Jin-lin Hu, Si-si Hu, Xiu-xiu Hou, Xin Zhu, Jun Cao, Lie-hao Jiang, Ming-hua Ge   +6 more
doaj   +1 more source

Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study [PDF]

, 2018
PURPOSE: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules.
Avenia, Nicola, Badii, Benedetta, Bellantone, Rocco, Boschin, Isabella Merante, Cal\uf2, Pietro Giorgio, Chiofalo, Maria Grazia, DI MAIO, Massimo, Fulciniti, Franco, Gallo, Ciro, Lombardi, Celestino Pio, Nicolosi, Angelo, Panebianco, Vincenzo, Pelizzo, Maria Rosa, Perigli, Giuliano, Perrone, Francesco, Pezzullo, Luciano, Polistena, Andrea, Ristagno, Serenella, Signoriello, Simona   +18 more
core   +4 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Fine needle biopsy in differential diagnosis of nodular goiter with autoimmune thyroiditis and differentiated thyroid cancers

Journal of Education, Health and Sport, 2017
We examined 75 women with nodular NGAIT and 12 patients with differentiated thyroid cancer during 2015-2016. We have carried out an immunohistochemical study by means of monoclonal antibodies against Fas, FasL, Bcl-2, P53 and Ki67 antigens using the ...
M. I. Sheremet, L. P. Sydorchuk, V. O. Shidlovskyi, A. D. Bedenyuk, A. I. Popovych, O. V. Lazaruk   +5 more
doaj   +3 more sources

Comparison of New and Old Versions of Guidelines for Diagnosis and Treatment of Thyroid Nodules and Differentiated Thyroid Carcinoma in China from A Surgical Perspective

Zhongliu Fangzhi Yanjiu
The set of guidelines for the diagnosis and treatment of thyroid nodules and differentiated thyroid cancer (the second edition) was published in 2023 in China.
YANG Tingting, SU Yanjun, CHENG Ruochuan
doaj   +1 more source

Detection rate of FNA cytology in medullary thyroid carcinoma. a meta-analysis [PDF]

, 2015
Background: The early detection of medullary thyroid carcinoma (MTC) can improve patient prognosis, because histological stage and patient age at diagnosis are highly relevant prognostic factors. As a consequence, delay in the diagnosis and/or incomplete
Anna, Crescenzi, Giorgio, Treglia, Leo, Guidobaldi, Luca, Giovanella, Massimo, Bongiovanni, Nigri, Giuseppe, Pierpaolo, Trimboli, Ramin, Sadeghi, Romanelli, Francesco, Valabrega, Stefano, William C., Faquin   +10 more
core   +1 more source

Differentiated Thyroid Cancer and Pregnancy [PDF]

Indian Journal of Surgery, 2013
Thyroid cancer is second most common malignancy diagnosed during pregnancy. Differentiated thyroid cancer (DTC) is more common in reproductive age group due to its association with oestrogen and human chorionic gonadotropin. Evaluation and management of DTC has changed from an aggressive approach, now, to a more conservative approach. Management of DTC
Shiny Sherlie, Varghese, Ashish, Varghese, Chris, Ayshford   +2 more
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Galectin-3 performance in histologic and cytologic assessment of thyroid nodules. A systematic review and meta-analysis [PDF]

, 2017
The literature on Galectin-3 (Gal-3) was systematically reviewed to achieve more robust information on its histologic reliability in identifying thyroid cancers and on the concordance between Gal-3 test in histologic and cytologic samples.
Crescenzi, Anna, Giovanella, Luca, Romanelli, Francesco, Trimboli, Pierpaolo, Virili, Camilla   +4 more
core   +1 more source