Results 51 to 60 of about 101,301 (304)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Simultaneous Papillary Carcinoma in Thyroglossal Duct Cyst and Thyroid [PDF]

, 2017
Thyroglossal duct cyst (TDC) is a cystic expansion of a remnant of the thyroglossal duct tract. Carcinomas in the TDC are extremely rare and are usually an incidental finding after the Sistrunk procedure.
Araújo Brandão Rajão, Kamilla Maria, Caldeira Araújo Sousa, Bárbara Érika, Cancela e Penna, Gustavo, Fonseca, Bernardo, Gomes Mendes, Henrique, José Martorina, Wagner, Koeppel Berenstein, Cynthia, Kraft, Adele O., Meyer de Moraes, Gustavo, N. R. de Souza, Andreise Laurian   +9 more
core   +4 more sources

The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC) [PDF]

, 2020
Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety.
D'Alessi S, Ferrara S, Florena AM, Galletti B, Galletti F, Gargano R, Greco G, Verro .   +7 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Unmodifiable variables related to thyroid cancer incidence [PDF]

, 2018
The incidence of thyroid cancer is significantly different between male and female patients. Thyroid cancer is also the only form of cancer where age can be considered a staging variable.
Alecu, Lucian, Hainarosie, Razvan, Jecan, Radu C., Nitipir, Cornelia, Orlov, Cristina, Pituru, Silviu, Slavu, Iulian, Stanculeanu, Dana L., Stoian, Anca P., Tulin, Adrian, Tulin, Raluca   +10 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Poorly differentiated papillary thyroid carcinoma in a 5-year-old girl: a case report

Egyptian Pediatric Association Gazette
Background The incidence of thyroid cancer has been increasing among the population less than 20 years of age, especially during the second decade of life. Differentiated papillary thyroid cancer is the most common pathology in children.
Mohanned Mohsen, Omar Hamdy, Ahmad Ramadan, Shadi Awny, Khaled Zalata, Mohamed Ezat   +5 more
doaj   +1 more source

Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer

Scientific Reports, 2021
The primary cilium is well-preserved in human differentiated thyroid cancers such as papillary and follicular carcinoma. Specific thyroid cancers such as Hürthle cell carcinoma, oncocytic variant of papillary thyroid carcinoma (PTC), and PTC with ...
Junguee Lee, Ki Cheol Park, Hae Joung Sul, Hyun Jung Hong, Kun-Ho Kim, Jukka Kero, Minho Shong   +6 more
doaj   +1 more source

HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer [PDF]

, 2015
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm and extra-cellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system ...
ANTONACI, Alfredo, FAGGIONI, Alberto, Fico, F., MARDENTE, Stefania, MARI, EMANUELA, MASSIMI, ISABELLA, PULCINELLI, FABIO MARIA, ZICARI, Alessandra   +7 more
core   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source