Results 231 to 240 of about 3,508,804 (299)

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay   +4 more
wiley   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik   +3 more
wiley   +1 more source

Improving the Accuracy of Papillary Thyroid Cancer Pathological Evaluation With Digital PCR Detection of the BRAF V600E Mutation

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study developed a highly sensitive and specific digital PCR assay for BRAF V600E mutation detection in papillary thyroid cancer (PTC). The increased sensitivity of BRAF mutation detection directly led to more accurate pathological diagnosis of PTC and in turn improved clinical care in patients with limited sample availability or in samples with ...
Na Yu   +11 more
wiley   +1 more source

Application of MR Cytometry in Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer: A Comparative Study

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MR cytometry imaging is developed to characterize in vivo microstructures. Its clinical value in predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for breast cancer remains unknown. Purpose To implement MR cytometry to predict pCR for breast cancer and compare the performance of different ...
Jie Ding   +10 more
wiley   +1 more source

Proteogenomic characterization delineates clinically relevant subtypes of advanced differentiated thyroid cancer. [PDF]

open access: yesCell Rep Med
Zhang T   +24 more
europepmc   +1 more source

Mapping the Landscape of Over‐Scanning in CT Imaging: A Scoping Review

open access: yesJournal of Medical Radiation Sciences, EarlyView.
Over‐scanning in CT is highly prevalent and contributes to unnecessary radiation exposure, with notable impact on radiosensitive organs. Standardised protocols and AI‐assisted planning show strong potential to optimise scan range and reduce excess dose.
Mo'men Bani‐Ahmad   +5 more
wiley   +1 more source

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