Results 31 to 40 of about 1,742 (133)

Unveiling a Dermatological Rarity: The Enigma of Vulvar Intraepithelial Neoplasia Grade III (HSIL) and the Role of p53 in Its Development

Biomedicines
Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia.
Piotr Brzeziński, Igor Feszak, Beatriz Di Martino Ortiz, Sylwia Feszak, Piotr Kawczak, Tomasz Bączek   +5 more
doaj   +1 more source

Human papillomavirus persistence and clearance in women living with HIV: A five‐year retrospective analysis from an Italian university center

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 2041-2047, October 2026.
In women living with HIV, HPV clearance occurred after a mean of approximately 2 years under antiretroviral therapy. Baseline positivity for the high‐risk HPV pool was associated with delayed clearance, suggesting that HPV genotype may influence viral persistence more than immunovirological status in clinically stable patients.
Annunziata Carlea, Dario Colacurci, Giorgia D'Apice, Laura Letizia Mazzarelli, Massimiliano Pellicano, Luigi Falco, Ginevra Sepe, Oriana Imperatore, Giuseppe Maria Maruotti, Maurizio Guida, Laura Sarno   +10 more
wiley   +1 more source

Active surveillance of cervical intraepithelial neoplasia and adverse pregnancy outcomes: A register‐based cohort study

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 2097-2103, October 2026.
Active surveillance for cervical intraepithelial neoplasia grade 2 is not associated with increased risks of adverse pregnancy outcomes compared to large loop excision of the transformation zone. Abstract Introduction Previous studies have suggested that human papillomavirus (HPV) and HPV‐related disease may be associated with increased risk of adverse
Kirstine Kold Katholm, Lotte Krog Eriksen, Kathrine Dyhr Lycke, Ninna Lund Larsen, Iben Sundtoft, Tina Hovgaard Randrup, Anne Hammer   +6 more
wiley   +1 more source

Atypical fibroxanthoma associated with differentiated-type vulvar intraepithelial neoplasia: Case report of an unusual entity [PDF]

JAAD Case Reports, 2019
Atypical fibroxanthoma associated withdifferentiated-type vulvar intraepithelialneoplasia: Case report of an unusual entity.
De Leo A., Ricci C., Terzano P., Santini D., Corti B.   +4 more
openaire   +3 more sources

Human papillomavirus in vulvar cancer: a systematic review

Инфекция и иммунитет
Introduction. Being considered as one of the most difficult to cure, vulvar malignant neoplasms belong to rare oncopathologies of the female reproductive system. It is established that vulvar squamous cell cancer develops via two pathways.
D. S. Dolgasheva, M. K. Ibragimova, E. A. Kravtsova, I. A. Tsydenova, K. A. Gaptulbarova, M. M. Tsyganov, N. V. Litviakov   +6 more
doaj   +1 more source

Characteristics of vaginal and vulvar microbiota in patients with vulvar precancerous lesions and vulvar squamous cell carcinoma

Journal of Education, Health and Sport
The aim of the study was to analyze the composition of the microbiota of the vagina and vulva in patients with precancerous lesions of the vulva in comparison with healthy controls and in women with vulvar cancer. Materials and methods.
V. Dunaevskaya
doaj   +1 more source

Long‐term outcome of ablation for anal HSIL: Achieving HSIL‐free status is key—A UK‐based retrospective cohort study

Colorectal Disease, Volume 28, Issue 9, September 2026.
Abstract Introduction Treating anal high‐grade squamous intraepithelial lesions (HSIL) reduces squamous cell carcinoma (SCC) rates in high‐risk groups such as men having sex with men (MSM), especially those living with HIV (LWH). Follow‐up data after HSIL treatment is lacking.
T. Cuming, K. Rozemeijer, E. Farrow, C. Cappello, B. Wait, M. Junejo, J. Bowring, A. N. Rosenthal, O. Richel, M. Nathan, H. J. C. de Vries, J. M. Prins   +11 more
wiley   +1 more source

Circulating MicroRNAs in Patients with Vulvar Squamous Cell Carcinoma and Its Precursors

Non-Coding RNA
Objectives: Vulvar squamous cell carcinoma (VSCC) is a rare gynecologic malignancy, with most cases arising from differentiated vulvar intraepithelial neoplasia (dVIN).
Julia Rymuza, Angelika Długosz, Kamil Zalewski, Artur Kowalik, Mateusz Bujko, Magdalena Kowalewska   +5 more
doaj   +1 more source

Analysis of Age, Period and Cohort Trends in Cervical In Situ and Invasive Carcinomas for Assessing the Utility of Screening Approaches—Results From the Saarland Cancer Registry

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Cervical cancer continues to pose a significant public health burden. In Germany, prevention relies heavily on regular screening and HPV vaccination. Objective To analyze trends in cervical cancer incidence over a 50‐year period in Saarland, Germany, with a focus on cohort effects and the impact of screening programs.
Natalie Rath, Klaus Neis, Bernd Holleczek   +2 more
wiley   +1 more source

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes, Aline Lopes Ribeiro, Rafaella Almeida Nunes, João Simão Sobrinho, Amanda Schiersner Caodaglio, Rossana Veronica Mendonza Lopez, Thais Rocha, Maria Luiza Nogueira Dias Genta, Konstanze Schichl, Ademola Aiyenuro, John Doorbar, Laura Sichero   +11 more
wiley   +1 more source